Compare Toprol XL vs. Propranolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Toprol XL
(metoprolol succinate)

Inderal
(propranolol)

Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.2Toprol XL
Reviews for Toprol XL
60%
of people (All ages) say Toprol XL is worth it
54%
say it works well
13%
say it's a big hassle
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Reviews for Propranolol
66%
-6% worse vs. Toprol XL
62%
-8% worse vs. Toprol XL
15%
+2% better vs. Toprol XL
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it
Side effects
Toprol XLPropranolol
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Dizziness/balance problems 1%
More Toprol XL side effects »
  • Dizziness 5%
  • Fatigue 2%
  • Constipation 3%
More Propranolol side effects »
How it works
Toprol XLPropranolol
Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
Toprol XLPropranolol
Prescription onlyPrescription only
Available as
Toprol XLPropranolol
  • Extended release
  • Pill
  • Extended release
  • Liquid
Used for
Toprol XLPropranolol
Risk factors for serious side effects
Toprol XLPropranolol
  • Sudden discontinuation of medicine
  • Coronary artery disease
  • Diabetes
  • Hyperthyroidsim
  • Heart failure
Detailed Toprol XL (metoprolol succinate) risks & warnings »
  • Suddenly stopping Inderal (Propranolol)
  • Major surgery requiring anesthesia
  • Diabetes
  • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
Detailed Inderal (propranolol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
Toprol XLPropranolol
  • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
  • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
  • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
  • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
  • It's available as a generic and is relatively cheap.
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
Downsides and risks
Toprol XLPropranolol
  • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
  • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
  • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
Toprol XLPropranolol
  • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
  • It can make you feel tired or give you headaches.
  • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
  • Don't stop taking this medicine suddenly.
  • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause insomnia and fatigue.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly.
Learn more
More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it