Compare Tradjenta vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tradjenta (linagliptin)

Prescription only

Actos (pioglitazone)

Prescription only
Lowers blood sugar.

Tradjenta (linagliptin) is good add-on medicine for controlling your blood sugar, but may cause body aches.

Lowers blood sugar.

Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.

4.1/ 7 average rating with 175 reviewsforActos
Upsides
  • Good add-on medicine if your blood sugars are still not controlled
  • Good option if you have bad liver or kidney function.
  • Can be taken once daily.
  • Does not cause weight gain.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
Downsides
  • Not first-choice anti-diabetes medicine because it doesn't lower blood sugar levels as much as others.
  • Available as brand only and may be expensive
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$398.11
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Lowest price near you
$12.05
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Reviews
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175 
42%
think this treatment is worth it
30%
think this treatment works well
21%
think this treatment is a hassle

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Side effects
6possible side effects
  • Back pain
    9%
  • Joint pain
    8%
  • Lung infection
    8%
  • Headache
    6%
  • Cough
    6%
  • Pain in the limbs
    5%
See more detailed side effects
10possible side effects
  • Low blood sugar
    27%
  • Swelling
    27%
  • Colds and flu
    13%
  • Headache
    9%
  • Heart failure
    8%
  • Sinus infection
    6%
  • Back pain
    6%
  • Pain in arms and legs
    6%
  • Muscle pain
    5%
  • Sore throat
    5%
See more detailed side effects
Risks and warnings
  • Inflammation of pancreas (pancreatitis)

    Alcoholism

    ...and 2 more risk factors

  • Low blood sugar (hypoglycemia)

    Alcoholism

    ...and 3 more risk factors

See more detailed risks and warnings
  • Heart failure

    Heart failure

  • Liver damage

    Current liver problems

  • Bladder cancer

    History of bladder cancer

  • Bone fracture

    Women

See more detailed risks and warnings