Compare Tradjenta vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tradjenta
(linagliptin)

Actos
(pioglitazone)

Lowers blood sugar. Tradjenta (linagliptin) is good add-on medicine for controlling your blood sugar, but may cause body aches.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
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Best available price for 30 (30mg) tablets of actos
Reviews & ratings
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Have you used Tradjenta (linagliptin)?
Worth itNot sureNot worth it
Reviews for Actos
42%
-42% worse vs. Tradjenta
30%
-30% worse vs. Tradjenta
21%
+21% better vs. Tradjenta
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
TradjentaActos
  • Common cold 1%
  • Cough 1%
  • Urinary tract infection 3%
  • High blood fat (triglyceride) 2%
  • High cholesterol 2%
  • Weight gain 1%
  • Constipation 1%
  • Back pain 9%
  • Joint pain 8%
More Tradjenta side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
TradjentaActos
Tradjenta (linagliptin) is an anti-diabetic medicine. It increases insulin and decreases glucagon production.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
TradjentaActos
Prescription onlyPrescription only
Available as
TradjentaActos
  • Pill
  • Pill
Used for
TradjentaActos
Risk factors for serious side effects
TradjentaActos
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Exercising more than you usually do
Detailed Tradjenta (linagliptin) risks & warnings »
  • Heart failure diagnosis
  • Current liver problems
  • Female
Detailed Actos (pioglitazone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
TradjentaActos
  • Take with or without meals.
No food related info.
Kidneys and liver
TradjentaActos
  • Good option if you have bad liver or kidney function.
No kidneys and liver related info.
Weight
TradjentaActos
  • Does not cause weight gain.
  • Can cause weight gain, headache, and fluid retention.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
Upsides and benefits
TradjentaActos
  • Good add-on medicine if your blood sugars are still not controlled
  • Good option if you have bad liver or kidney function.
  • Can be taken once daily.
  • Does not cause weight gain.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
Downsides and risks
TradjentaActos
  • Not first-choice anti-diabetes medicine because it doesn't lower blood sugar levels as much as others.
  • Available as brand only and may be expensive
  • May take several weeks to lower blood sugar.
  • You have to check your blood sugar regularly with this medicine.
  • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
  • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • Slightly raises the risk of bladder cancer.
Tips from our pharmacists for people taking the medication
TradjentaActos
  • Take with or without meals.
  • Maintain a consistent diet and exercise schedule to prevent changes in your blood sugar.
  • Takes several weeks to see full effect on blood sugar control.
  • Can cause weight gain, headache, and fluid retention.
  • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
  • Not recommended for patients with certain heart problems.
  • Check your blood sugar regularly.
Learn more
More about TradjentaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tradjenta (linagliptin)?
Worth itNot sureNot worth it
More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it