Compare Tradjenta vs. Invokamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tradjenta
(linagliptin)

Invokamet
(canagliflozin / metformin)

Lowers blood sugar. Tradjenta (linagliptin) is good add-on medicine for controlling your blood sugar, but may cause body aches.Lowers blood sugar. Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.
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Reviews & ratings
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Have you used Tradjenta (linagliptin)?
Worth itNot sureNot worth it

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Have you used Invokamet (canagliflozin / metformin)?
Worth itNot sureNot worth it
Side effects
TradjentaInvokamet
  • Common cold 1%
  • Cough 1%
  • Urinary tract infection 3%
  • High blood fat (triglyceride) 2%
  • High cholesterol 2%
  • Weight gain 1%
  • Constipation 1%
  • Back pain 9%
  • Joint pain 8%
More Tradjenta side effects »
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokamet side effects »
How it works
TradjentaInvokamet
Tradjenta (linagliptin) is an anti-diabetic medicine. It increases insulin and decreases glucagon production.Invokamet (canagliflozin / metformin) is a combination of anti-diabetes medicines. Metformin lowers blood sugar by enhancing your body's response to insulin, while canagliflozin increases your body's secretion of sugar through the urine.
Type of medication
TradjentaInvokamet
Prescription onlyPrescription only
Available as
TradjentaInvokamet
  • Pill
  • Pill
Used for
TradjentaInvokamet
Risk factors for serious side effects
TradjentaInvokamet
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Exercising more than you usually do
Detailed Tradjenta (linagliptin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Contrast dye for procedure
  • Surgery
Detailed Invokamet (canagliflozin / metformin) risks & warnings »
Pregnancy
Food
TradjentaInvokamet
  • Take with or without meals.
  • Take with meals to avoid an upset stomach.
Kidneys and liver
TradjentaInvokamet
  • Good option if you have bad liver or kidney function.
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
Pain
TradjentaInvokamet
No pain related info.
  • Invokamet (canagliflozin / metformin) can, in very rare cases, hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or are taking medicines for blood pressure or pain like NSAIDs. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokamet (canagliflozin / metformin).
Weight
TradjentaInvokamet
  • Does not cause weight gain.
  • Does not cause weight gain unlike other anti-diabetic medicines.
Upsides and benefits
TradjentaInvokamet
  • Good add-on medicine if your blood sugars are still not controlled
  • Good option if you have bad liver or kidney function.
  • Can be taken once daily.
  • Does not cause weight gain.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
Downsides and risks
TradjentaInvokamet
  • Not first-choice anti-diabetes medicine because it doesn't lower blood sugar levels as much as others.
  • Available as brand only and may be expensive
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
Tips from our pharmacists for people taking the medication
TradjentaInvokamet
  • Take with or without meals.
  • Maintain a consistent diet and exercise schedule to prevent changes in your blood sugar.
  • Take with meals to avoid an upset stomach.
  • Practice good hygiene to prevent yeast infections.
  • Can cause dehydration so be sure to drink plenty of fluids.
  • Make sure to continue a healthy diet and lifetyle.
Learn more
More about TradjentaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tradjenta (linagliptin)?
Worth itNot sureNot worth it
More about InvokametSide effectsAlternativesFDA package insert
Have you used Invokamet (canagliflozin / metformin)?
Worth itNot sureNot worth it