Compare tramadol vs. Percocet

Ultram (Tramadol) and Percocet (Oxycodone / Acetaminophen) are both pain relievers but Tramadol is an atypical opioid pain reliever while Percocet is a combination pain medicine which combines an opioid and non-opioid pain reliever. Tramadol works well to treat severe pain and mood changes and although it's a little weaker than other opioids, it can still be addictive. Percocet is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Treats moderate to severe pain.

Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.

3.4/ 5 average rating with 642 reviewsfortramadol
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

3.8/ 5 average rating with 1399 reviewsforPercocet
Upsides
  • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
  • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
  • Has a lower chance of causing breathing problems compared to other typical opioids.
  • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
  • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
  • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
  • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
  • Pill
  • Oral solution
Price
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Reviews
642 reviews so far
61%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Ultram (tramadol)?

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1399 reviews so far
70%
saidit'sworth it
49%
saiditworked well
15%
saidit'sa big hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
13possible side effects
  • Dizziness
    26%
  • Nausea
    24%
  • Constipation
    24%
  • Headache
    18%
  • Sleepiness
    16%
  • Vomiting
    9%
  • Pruritus
    8%
  • CNS Stimulation
    7%
  • Asthenia
    6%
  • Sweating
    6%
  • Dyspepsia
    5%
  • Dry Mouth
    5%
  • Diarrhea
    5%
See more detailed side effects
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Breathing problems
    • Age 65 or greater
    • Overdose
    • Using alcohol, benzodiazepines or other medicines that slow breathing
  • Addiction, abuse, and overdose
    • Taking more than the prescribed dose
    • Taking with alcohol or benzodiazepines
    • Stopping Ultram (tramadol) suddenly
  • Interactions with other drugs
  • Withdrawal in newborns
    • Pregnancy
  • Accidental ingestion
    • Children can reach medication
See more detailed risks and warnings
  • Death from liver failure
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
  • Death from lack of oxygen to the body (respiratory depression)
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Tolerance and dependence
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Neonatal withdrawal syndrome
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Death from overdose (extended-release tablet)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
  • Severe allergic reactions
  • Low blood pressure
    • Age 65 years or older
    • Circulation problems
See more detailed risks and warnings