Compare Tramadol vs. Percocet

Ultram (Tramadol) and Percocet (Oxycodone / Acetaminophen) are both pain relievers but Tramadol is an atypical opioid pain reliever while Percocet is a combination pain medicine which combines an opioid and non-opioid pain reliever. Tramadol works well to treat severe pain and mood changes and although it's a little weaker than other opioids, it can still be addictive. Percocet is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Ultram
(tramadol)

Percocet
(oxycodone / acetaminophen)

Treats moderate to severe pain. Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Prices and coupon for 120 (50mg) tablets of tramadol
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Prices and coupon for 120 (5mg/325mg) tablets of oxycodone / acetaminophen
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.62Tramadol
Reviews for Ultram (tramadol)
61%
of people (All ages) say Ultram (tramadol) is worth it
40%
say it works well
16%
say it's a big hassle
642 reviews
Have you used Ultram (tramadol)?
Worth itNot sureNot worth it
Reviews for Percocet (oxycodone / acetaminophen)
70%
+9% better vs. Ultram (tramadol)
49%
+9% better vs. Ultram (tramadol)
15%
+1% better vs. Ultram (tramadol)
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
TramadolPercocet
  • Dizziness 26%
  • Constipation 24%
  • Nausea 24%
  • Headache 18%
  • Sleepiness 16%
  • Vomiting 9%
  • Itching 8%
  • Cns stimulation 7%
  • Muscle weakness 6%
  • Sweating 6%
More Tramadol side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
TramadolPercocet
Ultram (tramadol) is an opioid pain reliever. Researchers don't know exactly how it works, but it alters certain brain chemicals to lower pain perception and improve mood.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
TramadolPercocet
Prescription only
Prescription only
Available as
TramadolPercocet
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
  • Pill
  • Oral solution
Used for
TramadolPercocet
Risk factors for serious side effects
TramadolPercocet
    • Pregnancy
    • Age 65 or greater
    • Overdose
    • Using alcohol, benzodiazepines or other medicines that slow breathing
    • Taking more than the prescribed dose
    • Taking with alcohol or benzodiazepines
    • Stopping Ultram (tramadol) suddenly
    • Children can reach medication
    Detailed Ultram (tramadol) risks & warnings »
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
      • Age 65 years or older
      • Circulation problems
      Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      TramadolPercocet
      • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
      No interactions related info.
      Alcohol
      TramadolPercocet
      No alcohol related info.
      • Avoid alcohol.
      Food
      TramadolPercocet
      • Take Ultram (tramadol) with food to avoid an upset stomach.
      • Take it with food to lower the chance of an upset stomach.
      Kidneys and liver
      TramadolPercocet
      • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
      • Don't take more than instructed to prevent liver damage.
      • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
      Pain
      TramadolPercocet
      • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
      • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
      • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
      • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
      • Generally considered stronger than Norco or other combination pain medicine for treating pain.
      • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
      • Works best if you take it as soon as you start feeling pain.
      • Pain relief lasts 4-6 hours.
      • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
      Sleep
      TramadolPercocet
      No sleep related info.
      • Can help you fall asleep easier.
      • Dizziness and drowsiness is common, but your body may adjust.
      Upsides and benefits
      TramadolPercocet
      • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
      • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
      • Has a lower chance of causing breathing problems compared to other typical opioids.
      • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
      • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
      • Provides quick relief for moderate to severe pain to improve quality of life.
      • Generally considered stronger than Norco or other combination pain medicine for treating pain.
      • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
      • Lower rates of misuse compared to pure opioid medicines.
      • Can help you fall asleep easier.
      Downsides and risks
      TramadolPercocet
      • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
      • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
      • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
      • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
      • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
      • Dizziness and drowsiness is common, but your body may adjust.
      • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
      • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
      • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
      • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
      • Avoid alcohol.
      Tips from our pharmacists for people taking the medication
      TramadolPercocet
      • Starts working in one hour and works best if you take it regularly.
      • Can make you dizzy or drowsy, so avoid activities that need you to be fully alert until you know how this medicine affects you.
      • Take Ultram (tramadol) with food to avoid an upset stomach.
      • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
      • Swallow the extended-release tablets whole. They're designed to release the drug slowly and breaking, crushing, or chewing them could cause a serious overdose.
      • Take the extended-release tablets exactly as your doctor and pharmacist tell you. If you forget, take it as soon as you remember. Don't take extra medicine to make up for a missed dose.
      • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
      • Starts working in 30 minutes.
      • Works best if you take it as soon as you start feeling pain.
      • Pain relief lasts 4-6 hours.
      • Can make you dizzy or drowsy.
      • Avoid activities need you to be fully alert until you know how it affects you.
      • Take it with food to lower the chance of an upset stomach.
      • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
      • Don't take more than instructed to prevent liver damage.
      • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
      • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
      Learn more
      More about TramadolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Ultram (tramadol)?
      Worth itNot sureNot worth it
      More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Percocet (oxycodone / acetaminophen)?
      Worth itNot sureNot worth it