Compare trifluoperazine vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stelazine
(trifluoperazine)

Clozaril
(clozapine)

Treats anxiety and schizophrenia. Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.Helps control your thoughts and actions. Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.
Reviews & ratings
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Have you used Stelazine (trifluoperazine)?
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Have you used Clozaril (clozapine)?
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Side effects
trifluoperazineClozaril

The trifluoperazine FDA package insert doesn’t have numbers about how common side effects are.

More about trifluoperazine side effects »
  • Drowsiness/sedation 39%
  • Salivation 31%
  • Abnormally fast heart beat 25%
  • Dizziness/vertigo 19%
  • Constipation 14%
  • Low blood pressure 9%
  • Headache 7%
  • Dry mouth 6%
  • Sweating 6%
  • Fainting 6%
More Clozaril side effects »
How it works
trifluoperazineClozaril
Stelazine (trifluoperazine) is a first generation (typical) antipsychotic. It works in schizophrenia by making the brain less sensitive to changes in dopamine, which helps regulate your mood.Clozaril (Clozapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
trifluoperazineClozaril
Prescription onlyPrescription only
Available as
trifluoperazineClozaril
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
Used for
trifluoperazineClozaril
Risk factors for serious side effects
trifluoperazineClozaril
  • People age 65 and older with dementia and psychosis
  • Women age 65 and older
  • Taking antipsychotic medications
  • History of low white or red blood cell counts
Detailed Stelazine (trifluoperazine) risks & warnings »
  • Dehydration
  • Taking blood pressure medications
  • Seizure disorder
  • Alcohol abuse
  • History of heart problems
Detailed Clozaril (clozapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
trifluoperazineClozaril
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Sleep
trifluoperazineClozaril
No sleep related info.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
Weight
trifluoperazineClozaril
No weight related info.
  • People on Clozaril (Clozapine) have reported weight gain. This is common. If this bothers you, talk to your doctor about what you can do to stop this from happening.
  • Can affect your weight, cholesterol, and blood sugar control.
Upsides and benefits
trifluoperazineClozaril
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
Downsides and risks
trifluoperazineClozaril
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Tips from our pharmacists for people taking the medication
trifluoperazineClozaril
  • Stelazine (trifluoperazine) can make you more sensitive to changes in temperature. If it's hot out, drink plenty of liquids, don't exercise too hard, and protect yourself from the sun. If it's cold, dress warm and don't stay outside too long.
  • Stelazine (trifluoperazine) can make you feel sleepy for the first few days. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
  • You might feel dizzy or faint the first few days you take Stelazine (trifluoperazine). Be very careful getting up if you've been sitting or lying down for a while.
  • If you want to stop taking Stelazine (trifluoperazine) and you've been taking it for at least a few months, talk to your doctor first.
  • Take Clozaril (Clozapine) exactly as prescribed and don't stop taking it without talking to your doctor.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Blood tests are needed before you start this medicine and before every refill. You need to pick up the medicine within 7 days of your blood tests.
  • Can affect your weight, cholesterol, and blood sugar control.
Learn more
More about trifluoperazineSide effectsAlternativesFDA package insert
Have you used Stelazine (trifluoperazine)?
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More about ClozarilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it