Compare trifluoperazine vs. Risperdal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stelazine (trifluoperazine)

Prescription only

Risperdal (risperidone)

Prescription only
Treats anxiety and schizophrenia.

Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.

Helps control your thoughts and mood.

Risperdal (risperidone) is an effective medication in treating schizophrenia, mania, and irritability associated with autism; however, amongst other newer medications in its class, it's more likely to cause side effects, such weight gain and hormone problems.

4.5/ 7 average rating with 45 reviewsforRisperdal
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
  • Risperdal (risperidone) is effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior. It also lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Less likely to cause heart problems compared to other antipsychotics.
  • Compared to other antipsychotics, Risperdal (risperidone) causes less sedation and weight gain.
  • A generic version available for pill, dissolving tablet, and liquid formulations.
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS) - movement disorders that cause stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • People taking Risperdal (risperidone) might have weight gain and problems with cholesterol or blood sugar.
  • Compared to other antipsychotics, this medication has a higher risk of hormone problems that can cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Risperdal (risperidone) takes 4 to 6 weeks for its full effects on thoughts and mood.
Used for
Dosage forms
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
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Side effects
The Stelazine (trifluoperazine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Sedation
  • Increased appetite
  • Fatigue
  • Vomiting
  • Common cold
  • Constipation
  • Cough
  • Fever
  • Involuntary urination
  • Drooling
See more detailed side effects
Risks and warnings
  • Higher risk of death in people age 65 and older with dementia

    People age 65 and older with dementia and psychosis

  • Difficulty controlling movements

    Women age 65 and older

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Changes in blood cell counts

    History of low white or red blood cell counts

See more detailed risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Shaking and restlessness

    High doses of Risperdal (risperidone)

  • Higher blood sugar and cholesterol and weight gain

    People with diabetes

    ...and 1 more risk factors

  • Driving impairment


    ...and 1 more risk factors

See more detailed risks and warnings