Compare trifluoperazine vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stelazine
(trifluoperazine)

Zyprexa
(olanzapine)

Treats anxiety and schizophrenia. Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.Helps control your thoughts and mood. Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.
Reviews & ratings
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Have you used Stelazine (trifluoperazine)?
Worth itNot sureNot worth it
Reviews for Zyprexa
41%
-41% worse vs. trifluoperazine
51%
-51% worse vs. trifluoperazine
51%
+51% better vs. trifluoperazine
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Side effects
trifluoperazineZyprexa

The trifluoperazine FDA package insert doesn’t have numbers about how common side effects are.

More about trifluoperazine side effects »
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Feeling dizzy/faint when standing up 3%
  • Akathisia (can't sit still) 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Weakness 9%
  • Stomach problems 6%
More Zyprexa side effects »
How it works
trifluoperazineZyprexa
Stelazine (trifluoperazine) is a first generation (typical) antipsychotic. It works in schizophrenia by making the brain less sensitive to changes in dopamine, which helps regulate your mood.Zyprexa (olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change chemical activity (like dopamine and serotonin) in your brain, which affects thoughts and mood.
Type of medication
trifluoperazineZyprexa
Prescription onlyPrescription only
Available as
trifluoperazineZyprexa
  • Pill
  • Pill
  • Dissolving tablet
  • Injection
Used for
trifluoperazineZyprexa
Risk factors for serious side effects
trifluoperazineZyprexa
  • People age 65 and older with dementia and psychosis
  • Women age 65 and older
  • Taking antipsychotic medications
  • History of low white or red blood cell counts
Detailed Stelazine (trifluoperazine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
trifluoperazineZyprexa
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
No alcohol related info.
Sleep
trifluoperazineZyprexa
No sleep related info.
  • Can cause dizziness and drowsiness.
  • Might make you more sleepy than some antipsychotics.
Weight
trifluoperazineZyprexa
No weight related info.
  • Zyprexa (olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Zyprexa (olanzapine) can also cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and increased cholesterol or blood sugar.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
Upsides and benefits
trifluoperazineZyprexa
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
Downsides and risks
trifluoperazineZyprexa
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
Tips from our pharmacists for people taking the medication
trifluoperazineZyprexa
  • Stelazine (trifluoperazine) can make you more sensitive to changes in temperature. If it's hot out, drink plenty of liquids, don't exercise too hard, and protect yourself from the sun. If it's cold, dress warm and don't stay outside too long.
  • Stelazine (trifluoperazine) can make you feel sleepy for the first few days. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
  • You might feel dizzy or faint the first few days you take Stelazine (trifluoperazine). Be very careful getting up if you've been sitting or lying down for a while.
  • If you want to stop taking Stelazine (trifluoperazine) and you've been taking it for at least a few months, talk to your doctor first.
  • Takes at least 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and increased cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take Zyprexa (olanzapine).
Learn more
More about trifluoperazineSide effectsAlternativesFDA package insert
Have you used Stelazine (trifluoperazine)?
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More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
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