Compare Trileptal vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevents seizures.

Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.

Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
  • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
  • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
  • Available in a generic form.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides
  • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
  • Interacts with many other medicines and supplements.
  • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Price
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Reviews
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97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

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Side effects
21possible side effects
  • Dizziness
    22%
  • Nausea
    16%
  • Headache
    13%
  • Any adverse effect
    9%
  • Diarrhea
    7%
  • Vomiting
    7%
  • Upper Respiratory Tract Infection
    7%
  • Constipation
    5%
  • Dyspepsia
    5%
  • Ataxia
    5%
  • Nervousness
    5%
  • Falling Down NOS
    4%
  • Pain Back
    4%
  • Amnesia
    4%
  • Coordination Abnormal
    4%
  • Tremor
    4%
  • Epistaxis
    4%
  • Infection Chest
    4%
  • Sinusitis
    4%
  • Rash
    4%
  • Vision Abnormal
    4%
See more detailed side effects
26possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
  • Anorexia
    12%
  • Amblyopia/Blurred Vision
    12%
  • Flu Syndrome
    12%
  • Infection
    12%
  • Dyspepsia
    8%
  • Ataxia
    8%
  • Nystagmus
    8%
  • Fever
    6%
  • Emotional Lability
    6%
  • Thinking Abnormal
    6%
  • Alopecia
    6%
  • Weight Loss
    6%
  • Constipation
    5%
  • Amnesia
    5%
  • Bronchitis
    5%
  • Rhinitis
    5%
See more detailed side effects
Risks and risk factors
  • Mental changes due to low sodium
    • Age 65 or older
    • dehydration
    • Taking diuretics (water pills)
  • Serious allergic reactions
    • Had allergic reaction to Tegretol (carbamazepine)
  • Life-threatnening skin reactions
    • Asian ancestry
  • Suicidal thoughts or behavior
    • History of depression
  • Withdrawal seizures
    • Stopping Trileptal (Oxcarbazepine) suddenly
  • Changes in blood cells
  • Bone disorders
    • History of osteoporosis
    • History of fractures
  • Liver problems
  • Low thyroid levels
    • Children
See more detailed risks and warnings
  • Pregnancy
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
  • Pancreatitis
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes due to high ammonia
    • History of metabolic disorders
    • People also taking Topamax
  • Low body temperature
    • People also taking Topamax
  • Serious allergic reactions
  • Withdrawal seizures
    • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
See more detailed risks and warnings