Compare Trileptal vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trileptal
(Oxcarbazepine)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Prevents seizures. Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
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Have you used Trileptal (Oxcarbazepine)?
Worth itNot sureNot worth it
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
21% vs. Trileptal (Oxcarbazepine)
40%
27% vs. Trileptal (Oxcarbazepine)
27%
5% vs. Trileptal (Oxcarbazepine)
Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
Worth itNot sureNot worth it
Side effects
TrileptalDepakote

The Trileptal FDA package insert doesn’t have numbers about how common side effects are.

More about Trileptal side effects »

The Depakote FDA package insert doesn’t have numbers about how common side effects are.

More about Depakote side effects »
How it works
TrileptalDepakote
Trileptal (Oxcarbazepine) is an antiepileptic medication. It reduces seizures by blocking certain types of nerve activity that regulate how your brain cells communicate with each other.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
TrileptalDepakote
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
TrileptalDepakote
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
TrileptalDepakote
Risk factors for serious side effects
TrileptalDepakote
  • Age 65 or older
  • dehydration
  • Taking diuretics (water pills)
  • Had allergic reaction to Tegretol (carbamazepine)
  • Asian ancestry
Detailed risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
  • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
TrileptalDepakote
  • Interacts with many other medicines and supplements.
No interactions related info.
Food
TrileptalDepakote
  • Trileptal (Oxcarbazepine) can be taken with or without food.
  • Take with food to avoid upset stomach.
Kidneys and liver
TrileptalDepakote
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Hepatitis and liver failure have been reported with Trileptal (Oxcarbazepine). However, this is very rare. Call your doctor right away if you start to have clay-colored stools, yellowing of the eyes or skin, dark urine, stomach pain, or if you are eating less than usual without trying to.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
Sleep
TrileptalDepakote
  • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
  • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
  • Trileptal (Oxcarbazepine) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
No sleep related info.
Weight
TrileptalDepakote
No weight related info.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • May cause hair loss and weight gain.
Upsides and benefits
TrileptalDepakote
  • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
  • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
  • Available in a generic form.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides and risks
TrileptalDepakote
  • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
  • Interacts with many other medicines and supplements.
  • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
TrileptalDepakote
  • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
  • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
  • If you need to stop taking Trileptal (Oxcarbazepine), do so over at least one week to prevent withdrawal seizures.
  • Trileptal (Oxcarbazepine) makes birth control and many other medicines less effective.
  • Trileptal (Oxcarbazepine) can be taken with or without food.
  • If you're taking the oral suspension, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about TrileptalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trileptal (Oxcarbazepine)?
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More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
Worth itNot sureNot worth it