Compare Trileptal vs. Keppra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trileptal
(Oxcarbazepine)

Keppra
(Levetiracetam)

Prevents seizures. Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.Prevents seizures. Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.
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Reviews & ratings
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Side effects
TrileptalKeppra
  • Dizziness 16%
  • Diarrhea 5%
  • Nausea 4%
  • Nervousness 3%
  • Headache 3%
  • Coordination abnormal 2%
  • Pain back 2%
  • Sinus inflammation 2%
  • Rash 2%
  • Amnesia 2%
More Trileptal side effects »
  • Drowsiness 7%
  • Nasal congestion 7%
  • Muscle weakness 6%
  • Neck pain 6%
  • Decreased appetite 6%
  • Fatigue 6%
  • Infection 5%
  • Aggression 5%
  • Dizziness 5%
  • Headache 4%
More Keppra side effects »
How it works
TrileptalKeppra
Trileptal (Oxcarbazepine) is an antiepileptic medication. It reduces seizures by blocking certain types of nerve activity that regulate how your brain cells communicate with each other.Keppra (Levetiracetam) is an antiepileptic medication. It prevents seizures by helping regulate neurotransmitters in the brain.
Type of medication
TrileptalKeppra
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
TrileptalKeppra
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
TrileptalKeppra
Risk factors for serious side effects
TrileptalKeppra
  • Age 65 or older
  • dehydration
  • Taking diuretics (water pills)
  • Had allergic reaction to Tegretol (carbamazepine)
  • Asian ancestry
  • History of depression
  • Stopping Trileptal (Oxcarbazepine) suddenly
    • History of osteoporosis
    • History of fractures
      • Children
      Detailed Trileptal (Oxcarbazepine) risks & warnings »
          • History of depression
          • Starting the first month of therapy
          • Taking with alcohol
          • Taking other medicines that make you less alert
          • Stopping Keppra (Levetiracetam) suddenly
          • History of psychiatric problems
          • Ages less than 18
          Detailed Keppra (Levetiracetam) risks & warnings »
          Pregnancy category
          TrileptalKeppra
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Trileptal (Oxcarbazepine) can be taken with or without food.
          No specific food-related info.
          Kidneys and liver
          • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
          • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
          • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
          • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
          Weight
          • Hypothyroidism (low thyroid levels) have been reported with Trileptal (Oxcarbazepine). Your thyroid levels may need to be tested regularly, Let your doctor know if you are more fatigued, gaining weight without any apparent reason, feeling more depressed, or are more sensitive to cold.
          No specific weight-related info.
          Upsides and benefits
          TrileptalKeppra
          • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
          • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
          • Available in a generic form.
          • You won’t need to get regular blood tests to check the drug levels in your body.
          • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
          • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
          • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
          • You won’t need to get regular blood tests to check the drug levels in your body.
          Downsides and risks
          TrileptalKeppra
          • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
          • Interacts with many other medicines and supplements.
          • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
          • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
          • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
          • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
          • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
          • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
          • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
          Tips from our pharmacists for people taking the medication
          TrileptalKeppra
          • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
          • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
          • If you need to stop taking Trileptal (Oxcarbazepine), do so over at least one week to prevent withdrawal seizures.
          • Trileptal (Oxcarbazepine) makes birth control and many other medicines less effective.
          • Trileptal (Oxcarbazepine) can be taken with or without food.
          • If you're taking the oral suspension, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
          • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
          • If you start having skin rashes or changes in your mood, tell your doctor immediately.
          • If you need to stop taking Keppra (Levetiracetam), do so over at least one week to prevent withdrawal seizures.
          • If you are taking the oral solution, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
          • Don’t crush or cut this medicine before taking it, or else you’ll have dangerously high levels of this drug in your body.
          Learn more
          More about TrileptalSide effectsReviews & ratingsAlternativesFDA package insert
          More about KeppraSide effectsReviews & ratingsAlternativesFDA package insert