Compare Trilipix vs. Simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(Fenofibric Acid)

Zocor
(Simvastatin)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Trilipix
Reviews for Trilipix (Fenofibric Acid)
50%
of people (All ages) say Trilipix (Fenofibric Acid) is worth it
22%
say it works well
25%
say it's a big hassle
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
Reviews for Zocor (Simvastatin)
61%
+11% vs. Trilipix (Fenofibric Acid)
48%
+26% vs. Trilipix (Fenofibric Acid)
14%
+11% vs. Trilipix (Fenofibric Acid)
1176 reviews
Have you used Zocor (Simvastatin)?
Worth itNot sureNot worth it
Side effects
TrilipixSimvastatin
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
More Trilipix side effects »

The Simvastatin FDA package insert doesn’t have numbers about how common side effects are.

More about Simvastatin side effects »
How it works
TrilipixSimvastatin
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
TrilipixSimvastatin
Cholesterol-lowering
Fibric acid
Prescription only
Cholesterol-lowering
Statin
Prescription only
Available as
TrilipixSimvastatin
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for (click to learn more)
TrilipixSimvastatin
Risk factors for serious side effects
TrilipixSimvastatin
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed risks & warnings »
  • Kidney disease
  • High dose of Zocor (Simvastatin)
  • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
TrilipixSimvastatin
No interactions related info.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
Alcohol
TrilipixSimvastatin
No alcohol related info.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
Kidneys and liver
TrilipixSimvastatin
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
  • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
Pain
TrilipixSimvastatin
No pain related info.
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
Upsides and benefits
TrilipixSimvastatin
  • Good medicine for lowering triglycerides.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
TrilipixSimvastatin
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
TrilipixSimvastatin
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
Learn more
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zocor (Simvastatin)?
Worth itNot sureNot worth it