Compare Trilipix vs. simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(fenofibric acid)

Zocor
(simvastatin)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Zocor (simvastatin) is a good medication to improve your cholesterol.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Trilipix
Reviews for Trilipix
50%
of people (All ages) say Trilipix is worth it
22%
say it works well
25%
say it's a big hassle
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
Reviews for simvastatin
61%
-11% worse vs. Trilipix
48%
-26% worse vs. Trilipix
14%
-11% worse vs. Trilipix
1176 reviews
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it
Side effects
Trilipixsimvastatin
  • Headache 13%
  • Back pain 6%
  • Pain in extremity 5%
  • Ear, nose, or throat infection 5%
  • Nausea 4%
  • Common cold 4%
  • Diarrhea 4%
  • Joint pain 4%
  • Pain 4%
  • Dizziness 4%
More Trilipix side effects »
  • Bronchitis 1%
  • Abnormal heart rhythm 1%
  • Scaly, itchy rash 2%
  • Stomach problems 1%
  • Balance problems 1%
  • Headache 1%
More simvastatin side effects »
How it works
Trilipixsimvastatin
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Zocor (simvastatin) is cholesterol-lowering medicine called a statin. It helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
Trilipixsimvastatin
Prescription onlyPrescription only
Available as
Trilipixsimvastatin
  • Pill
  • Extended release
  • Pill
Used for
Trilipixsimvastatin
Risk factors for serious side effects
Trilipixsimvastatin
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed Trilipix (fenofibric acid) risks & warnings »
  • Kidney disease
  • High dose of Zocor (simvastatin)
  • Combining Zocor (simvastatin) with other cholesterol-lowering drugs
  • Older age
  • Female gender
Detailed Zocor (simvastatin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
Trilipixsimvastatin
No interactions related info.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist about the medicines you are taking.
  • Can have more drug interactions than some other drugs in the same class (statins).
Alcohol
Trilipixsimvastatin
No alcohol related info.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
Kidneys and liver
Trilipixsimvastatin
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
  • People on Zocor (simvastatin) have reported muscle pain, which may lead to muscle and kidney damage. This is more likely to happen if you take higher doses of Zocor (simvastatin). If you suddenly feel muscle pain, weakness or fever and you haven't been exercising, stop taking Zocor (simvastatin) and talk to your doctor right away.
  • There are reports of liver damage in people who take Zocor (simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function regularly.
Pain
Trilipixsimvastatin
No pain related info.
  • Combining certain medications can increase the risk of muscle pain, muscle damage, and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
Upsides and benefits
Trilipixsimvastatin
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Available in generic.
  • Available in combination pills with other cholesterol medicines.
Downsides and risks
Trilipixsimvastatin
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Can have more drug interactions than some other drugs in the same class (statins).
Tips from our pharmacists for people taking the medication
Trilipixsimvastatin
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist about the medicines you are taking.
Learn more
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
More about simvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it