Compare Trilipix vs. Simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(Fenofibric Acid)

Zocor
(Simvastatin)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Zocor (Simvastatin) is a good medication to improve your cholesterol. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.791044776119403Trilipix
Reviews for Trilipix (Fenofibric Acid)
49%
of people say Trilipix (Fenofibric Acid) is worth it
22%
say it works well
25%
say it's a big hassle
Reviews for Zocor (Simvastatin)
61%
+12% vs. Trilipix (Fenofibric Acid)
48%
+26% vs. Trilipix (Fenofibric Acid)
14%
+11% vs. Trilipix (Fenofibric Acid)
Side effects
TrilipixSimvastatin
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
  • Upset stomach 3%
  • Scaly, itchy rash 2%
  • Bronchitis 1%
  • Vertigo 1%
  • Muscle pain 1%
  • Edema/swelling 1%
  • Abnormal heart rhythm 1%
More Simvastatin side effects »
How it works
TrilipixSimvastatin
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Zocor (Simvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
TrilipixSimvastatin
Cholesterol-lowering
Fibric acid
Prescription only
Cholesterol-lowering
Statin
Prescription only
Available as
TrilipixSimvastatin
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for (click to learn more)
TrilipixSimvastatin
Risk factors for serious side effects
TrilipixSimvastatin
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (Fenofibric Acid) risks & warnings »
              • Kidney disease
              • High dose of Zocor (Simvastatin)
              • Combining Zocor (Simvastatin) with certain cholesterol-lowering drugs
              • Older age and female gender
              • Heavy alcohol use
              • History of chronic liver disease
              • Pregnancy
              • Breast feeding
              • Certain drugs can increase the dose of Zocor (Simvastatin) in the body
                Detailed Zocor (Simvastatin) risks & warnings »
                Pregnancy category
                TrilipixSimvastatin
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                XFDA pregnancy category (Unsafe)

                Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • There are reports of liver damage in people who take Zocor (Simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
                Food
                No specific food-related info.No specific food-related info.
                Kidneys and liver
                • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • There are rare cases of muscle damage leading to kidney failure in people taking Zocor (Simvastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
                • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                TrilipixSimvastatin
                • Good medicine for lowering triglycerides.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                Downsides and risks
                TrilipixSimvastatin
                • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                • Different forms and strengths of this medication can't be substituted for each other.
                • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
                • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
                • Not safe to use if you're pregnant.
                Tips from our pharmacists for people taking the medication
                TrilipixSimvastatin
                • Can be used with other medications to help lower cholesterol.
                • Lowers triglycerides.
                • Can raise your chance of getting colds and flu.
                • Call your doctor if you develop muscle or abdominal pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
                • Most people reach their target cholesterol levels in 4 to 6 weeks.
                • Avoid grapefruit and grapefruit juice while taking this medicine.
                • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
                • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
                • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
                Learn more
                More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
                More about SimvastatinSide effectsReviews & ratingsAlternativesFDA package insert