Compare Trilipix vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(Fenofibric Acid)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Trilipix
Reviews for Trilipix (Fenofibric Acid)
50%
of people (All ages) say Trilipix (Fenofibric Acid) is worth it
22%
say it works well
25%
say it's a big hassle
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
Reviews for Vytorin (Ezetimibe / Simvastatin)
53%
+3% better vs. Trilipix (Fenofibric Acid)
36%
+14% better vs. Trilipix (Fenofibric Acid)
19%
+6% better vs. Trilipix (Fenofibric Acid)
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
Side effects
TrilipixVytorin
  • Headache 13%
  • Back pain 6%
  • Pain in extremity 5%
  • Ear, nose, or throat infection 5%
  • Nausea 4%
  • Common cold 4%
  • Diarrhea 4%
  • Joint pain 4%
  • Pain 4%
  • Dizziness 4%
More Trilipix side effects »
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
How it works
TrilipixVytorin
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
TrilipixVytorin
Prescription only
Prescription only
Available as
TrilipixVytorin
  • Pill
  • Extended release
  • Pill
Used for
TrilipixVytorin
Risk factors for serious side effects
TrilipixVytorin
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (Fenofibric Acid) risks & warnings »
              • Asian patients taking high-dose niacin
              • Past history of liver disease
              • heavy alcohol use
              • Diabetes
                  • Pregnancy
                  Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
                  Pregnancy

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                  Kidneys and liver
                  TrilipixVytorin
                  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
                  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
                  Upsides and benefits
                  TrilipixVytorin
                  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                  • Good medicine for lowering triglycerides.
                  • A 2-in-1 cholesterol-lowering combination medicine.
                  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                  Downsides and risks
                  TrilipixVytorin
                  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                  • Different forms and strengths of this medication can't be substituted for each other.
                  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
                  • There's no generic available, so it can be expensive.
                  Tips from our pharmacists for people taking the medication
                  TrilipixVytorin
                  • Can be used with other medications to help lower cholesterol.
                  • Lowers triglycerides.
                  • Can raise your chance of getting colds and flu.
                  • Call your doctor if you develop muscle or abdominal pain.
                  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                  • Take it in the evening.
                  • Avoid grapefruit and grapefruit juice while taking this medicine.
                  • Can cause headaches or diarrhea.
                  • Call your doctor if you develop muscle pain.
                  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                  Learn more
                  More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Trilipix (Fenofibric Acid)?
                  Worth itNot sureNot worth it
                  More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Vytorin (Ezetimibe / Simvastatin)?
                  Worth itNot sureNot worth it