Compare Trilipix vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(Fenofibric Acid)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.791044776119403Trilipix
Reviews for Trilipix (Fenofibric Acid)
49%
of people say Trilipix (Fenofibric Acid) is worth it
22%
say it works well
25%
say it's a big hassle
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
+3% vs. Trilipix (Fenofibric Acid)
36%
+14% vs. Trilipix (Fenofibric Acid)
19%
+6% vs. Trilipix (Fenofibric Acid)
Side effects
TrilipixVytorin
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
How it works
TrilipixVytorin
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
TrilipixVytorin
Cholesterol-lowering
Fibric acid
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Available as
TrilipixVytorin
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
TrilipixVytorin
Risk factors for serious side effects
TrilipixVytorin
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (Fenofibric Acid) risks & warnings »
              • Asian patients taking high-dose niacin
              • Past history of liver disease
              • heavy alcohol use
              • Diabetes
                  • Pregnancy
                  Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
                  Pregnancy category
                  TrilipixVytorin
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  XFDA pregnancy category (Unsafe)

                  Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.
                  • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
                  Food
                  No specific food-related info.No specific food-related info.
                  Kidneys and liver
                  • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  No specific sleep-related info.No specific sleep-related info.
                  Weight
                  No specific weight-related info.No specific weight-related info.
                  Upsides and benefits
                  TrilipixVytorin
                  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                  • Good medicine for lowering triglycerides.
                  • A 2-in-1 cholesterol-lowering combination medicine.
                  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                  Downsides and risks
                  TrilipixVytorin
                  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                  • Different forms and strengths of this medication can't be substituted for each other.
                  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
                  • There's no generic available, so it can be expensive.
                  Tips from our pharmacists for people taking the medication
                  TrilipixVytorin
                  • Can be used with other medications to help lower cholesterol.
                  • Lowers triglycerides.
                  • Can raise your chance of getting colds and flu.
                  • Call your doctor if you develop muscle or abdominal pain.
                  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                  • Take it in the evening.
                  • Avoid grapefruit and grapefruit juice while taking this medicine.
                  • Can cause headaches or diarrhea.
                  • Call your doctor if you develop muscle pain.
                  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                  Learn more
                  More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
                  More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert