Compare Trilipix vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(Fenofibric Acid)

Zetia
(Ezetimibe)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.
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Reviews & ratings
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3.791044776119403Trilipix
Reviews for Trilipix (Fenofibric Acid)
49%
of people (All ages) say Trilipix (Fenofibric Acid) is worth it
22%
say it works well
25%
say it's a big hassle
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
Reviews for Zetia (Ezetimibe)
42%
7% vs. Trilipix (Fenofibric Acid)
34%
+12% vs. Trilipix (Fenofibric Acid)
20%
+5% vs. Trilipix (Fenofibric Acid)
127 reviews
Have you used Zetia (Ezetimibe)?
Worth itNot sureNot worth it
Side effects
TrilipixZetia
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
How it works
TrilipixZetia
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.
Type of medication
TrilipixZetia
Cholesterol-lowering
Fibric acid
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Prescription only
Available as
TrilipixZetia
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
TrilipixZetia
Risk factors for serious side effects
TrilipixZetia
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (Fenofibric Acid) risks & warnings »
                • Taking Zetia (Ezetimibe) with statins
                • Past history of liver disease
                • Taking Zetia (Ezetimibe) with statins
                Detailed Zetia (Ezetimibe) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Kidneys and liver
                TrilipixZetia
                • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
                • Reports of liver disease have been reported in people who take Zetia (Ezetimibe), especially if taken with statins. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
                Upsides and benefits
                TrilipixZetia
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Good medicine for lowering triglycerides.
                • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Can be used with other medicines to improve cholesterol.
                • Available in a combination pill with simvastatin.
                Downsides and risks
                TrilipixZetia
                • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                • Different forms and strengths of this medication can't be substituted for each other.
                • Doesn't lower triglycerides (fats).
                • Hasn't been shown to lower the risk of heart attacks or heart disease.
                • By itself, Zetia is not as effective as statins for improving cholesterol.
                • There's no generic available, so it can be expensive.
                Tips from our pharmacists for people taking the medication
                TrilipixZetia
                • Can be used with other medications to help lower cholesterol.
                • Lowers triglycerides.
                • Can raise your chance of getting colds and flu.
                • Call your doctor if you develop muscle or abdominal pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                • Lowers bad cholesterol, and raises good cholesterol.
                • Tell your doctor if you develop bone or muscle pain.
                • Can be used with other medications to lower cholesterol.
                • May cause diarrhea or raise your chance of getting colds.
                Learn more
                More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Trilipix (Fenofibric Acid)?
                Worth itNot sureNot worth it
                More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Zetia (Ezetimibe)?
                Worth itNot sureNot worth it