Compare Trilipix vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(fenofibric acid)

Zetia
(ezetimibe)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.
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Coupons for Trilipix
Best available price for 30 (105mg) tablets of fenofibric acid
Coupons for Zetia
Best available price for 30 (10mg) tablets of ezetimibe
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.79Trilipix
Reviews for Trilipix (fenofibric acid)
50%
of people (All ages) say Trilipix (fenofibric acid) is worth it
22%
say it works well
25%
say it's a big hassle
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
Reviews for Zetia (ezetimibe)
42%
-8% worse vs. Trilipix (fenofibric acid)
34%
+12% better vs. Trilipix (fenofibric acid)
21%
+4% better vs. Trilipix (fenofibric acid)
128 reviews
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it
Side effects
TrilipixZetia
  • Headache 13%
  • Back pain 6%
  • Pain in extremity 5%
  • Ear, nose, or throat infection 5%
  • Nausea 4%
  • Common cold 4%
  • Diarrhea 4%
  • Joint pain 4%
  • Pain 4%
  • Dizziness 4%
More Trilipix side effects »
  • Common cold 1%
  • Sore throat 4%
  • Sinus infection 1%
  • Abnormal liver tests 3%
  • Joint pain 1%
  • Pain in arms and legs 1%
  • Muscle pain 3%
More Zetia side effects »
How it works
TrilipixZetia
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Zetia (ezetimibe) is a cholesterol-lowering medicine. It stops your body from absorbing cholesterol in food and helps process other forms of cholesterol.
Type of medication
TrilipixZetia
Prescription only
Prescription only
Available as
TrilipixZetia
  • Pill
  • Extended release
  • Pill
Used for
TrilipixZetia
Risk factors for serious side effects
TrilipixZetia
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed Trilipix (fenofibric acid) risks & warnings »
  • Taking Zetia (ezetimibe) with statins
  • Past history of liver disease
Detailed Zetia (ezetimibe) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
TrilipixZetia
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
  • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
Pain
TrilipixZetia
No pain related info.
  • Zetia (ezetimibe) can hurt your liver, especially if it is used with statins. Talk to your doctor if you have liver disease.
Upsides and benefits
TrilipixZetia
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
Downsides and risks
TrilipixZetia
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
Tips from our pharmacists for people taking the medication
TrilipixZetia
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Lowers bad cholesterol and raises good cholesterol.
  • Tell your doctor if you develop bone or muscle pain.
  • Can be used with other medications to lower cholesterol.
  • Good alternative to statins if you can't tolerate statins or are unable to control cholesterol with statins alone.
  • Can cause diarrhea or increase your chance of getting colds.
Learn more
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zetia (ezetimibe)?
Worth itNot sureNot worth it