Compare Trilipix vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilipix
(Fenofibric Acid)

Zetia
(Ezetimibe)

Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.Lowers cholesterol. Zetia can improve your cholesterol, but it doesn't reduce heart attacks or heart disease, and it's expensive compared to other cholesterol-lowering medicines.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.791044776119403Trilipix
Reviews for Trilipix (Fenofibric Acid)
49%
of people say Trilipix (Fenofibric Acid) is worth it
22%
say it works well
25%
say it's a big hassle
Reviews for Zetia (Ezetimibe)
42%
7% vs. Trilipix (Fenofibric Acid)
34%
+12% vs. Trilipix (Fenofibric Acid)
20%
+5% vs. Trilipix (Fenofibric Acid)
Side effects
TrilipixZetia
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
  • Ear, nose, or throat infection 1%
  • Sinus inflammation 1%
  • Arthtralgia 1%
More Zetia side effects »
How it works
TrilipixZetia
Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).Zetia is a cholesterol-lowering medicine. It prevents cholesterol absorption in your intestines, lowers the amount of cholesterol stored in your liver, and helps your body process cholesterol.
Type of medication
TrilipixZetia
Cholesterol-lowering
Fibric acid
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Prescription only
Available as
TrilipixZetia
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
TrilipixZetia
Risk factors for serious side effects
TrilipixZetia
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (Fenofibric Acid) risks & warnings »
                • Taking Zetia (Ezetimibe) with statins
                • Past history of liver disease
                • Taking Zetia (Ezetimibe) with statins
                Detailed Zetia (Ezetimibe) risks & warnings »
                Pregnancy category
                TrilipixZetia
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                No specific food-related info.No specific food-related info.
                Kidneys and liver
                • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                • People on Zetia (Ezetimibe) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                TrilipixZetia
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Good medicine for lowering triglycerides.
                • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Can be used with other medicines to improve cholesterol.
                • Available in a combination pill with simvastatin.
                Downsides and risks
                TrilipixZetia
                • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                • Different forms and strengths of this medication can't be substituted for each other.
                • Doesn't lower triglycerides (fats).
                • Hasn't been shown to lower the risk of heart attacks or heart disease.
                • By itself, Zetia is not as effective as statins for improving cholesterol.
                • There's no generic available, so it can be expensive.
                Tips from our pharmacists for people taking the medication
                TrilipixZetia
                • Can be used with other medications to help lower cholesterol.
                • Lowers triglycerides.
                • Can raise your chance of getting colds and flu.
                • Call your doctor if you develop muscle or abdominal pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                • Lowers bad cholesterol, and raises good cholesterol.
                • Tell your doctor if you develop bone or muscle pain.
                • Can be used with other medications to lower cholesterol.
                • May cause diarrhea or raise your chance of getting colds.
                Learn more
                More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
                More about ZetiaSide effectsReviews & ratingsAlternativesFDA package insert