Compare Truvada vs. Isentress

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Works with other medications to treat HIV infection, or works alone to prevent HIV infection.

Truvada (emtricitabine / tenofovir) is a versatile, first-choice HIV medication that is used in combination with other HIV medications to treat and prevent HIV infections.

4.8/ 5 average rating with 16 reviewsforTruvada
Works with other medicications to treat HIV infection.

Isentress (raltegravir) is considered a first choice to be used with other medications for treating HIV, but it can have more side effects than other similar medicines.

Upsides
  • Contains two first-choice medications which can be used in combination with other drugs to treat HIV infection.
  • Truvada (emtricitabine / tenofovir) is also a first-choice option to be used for preventing HIV.
  • Take only once daily, with or without food.
  • Isentress (raltegravir) is a first choice treatment to use together with other medications to treat HIV.
  • If you have difficulty swallowing the tablet, there is a chewable tablet or oral suspension available.
  • Can be used by children 4 weeks and older.
  • People with mild to moderate kidney or liver damage can use Isentress (raltegravir).
Downsides
  • If you're taking Truvada (emtricitabine / tenofovir) to stop you from getting HIV, you should continue having safe sex since it won't protect you from other sexually transmitted infections.
  • If you're taking Truvada (emtricitabine / tenofovir) to stop you from getting HIV, you have to get blood tests every 3 months to check for overall health and to make sure you don't have HIV or other sexually transmitted infections.
  • People with poorly functioning kidneys shouldn't take Truvada (emtricitabine / tenofovir).
  • Can weaken your bones.
  • If you have HIV as well as Hepatitis B and stop taking Truvada (emtricitabine / tenofovir) suddenly, your hepatitis may get worse.
  • It might be hard to remember to take Isentress (raltegravir) two times a day. Other similar medicines are once a day.
  • The chewable tablets contain phenylalanine and should be avoided in people who have phenylketonuria.
  • Isentress (raltegravir) cannot be used alone to treat or prevent HIV. It must be used together with other medications.
  • Not available as part of a combination tablet, so you'll have to take more tablets daily compared to other combinations.
Used for
  • HIV treatment
  • HIV prevention
Dosage forms
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Price
Lowest price
$1605.96
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Lowest price
$1424.38
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Reviews
16 reviews so far
100%
saidit'sworth it
94%
saiditworked well
0%
saidit'sa big hassle

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Side effects
12possible side effects
  • Diarrhea
    9%
  • Nausea
    9%
  • Fatigue
    9%
  • Depression
    9%
  • Stuffy or runny nose
    8%
  • Flu or bronchitis
    8%
  • Dizziness
    8%
  • Rash event
    7%
  • Headache
    6%
  • Common cold
    5%
  • Insomnia
    5%
  • Vomiting
    2%
See more detailed side effects
5possible side effects
  • Headache
    4%
  • Insomnia
    4%
  • Nausea
    3%
  • Fatigue
    2%
  • Dizziness
    2%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Worsening hepatitis B infection
    • Hepatitis B Virus infection
  • Kidney damage
    • History of kidney damage
    • Concurrent use of other drugs known to harm kidneys
  • Bone loss/osteoporosis
    • History of bone fractures
    • Osteoporosis
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Drug resistance while using pre-exposure prophylaxis (PrEP)
    • Undiscovered HIV infection while on PrEP
See more detailed risks and warnings
  • Severe skin reactions
    • Prior severe allergic reaction to Isentress
  • Allergic reactions
    • Prior severe allergic reaction to Isentress
  • Rhabdomyolysis (Muscle damage)
    • Concurrent use of other drugs which can cause muscle pain/damage
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.