Compare Truvada vs. Prezista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Truvada
(Emtricitabine / Tenofovir)

Prezista
(Darunavir)

Works with other medicines to treat HIV infection. Truvada (Emtricitabine / Tenofovir) is a popular combination medicine that has two drugs with the same mechanism of action to treat and prevent HIV infection.Coming soon.
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Reviews & ratings
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Side effects
TruvadaPrezista
  • > 5% bone mineral density loss 7%
  • Abdominal pain 2%
  • Secondary syphilis 2%
  • Headache 1%
  • Bone fractures 1%
  • Weight decreased 1%
  • Syphilis 1%
More Truvada side effects »

We haven’t found good data for Prezista side effects.

FDA side effect reports for Prezista »
How it works
TruvadaPrezista
Truvada (Emtricitabine / Tenofovir) is a combination medication that stops the replication of the human immunodeficiency virus (HIV) within important cells of the body. Emtricitabine and tenofovir both prevent the virus from taking over normal functions of the cell for its own purposes.Coming soon.
Type of medication
TruvadaPrezista
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Prescription only
Coming soon.
Available as
TruvadaPrezista
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
TruvadaPrezista
  • HIV infection
Risk factors for serious side effects
TruvadaPrezista
    • Infection with chronic hepatitis B and stopping Truvada (Emtricitabine / Tenofovir)
    • Taking high dose anti-inflammatory drugs (NSAIDs)
        • Undiscovered HIV infection
        Detailed Truvada (Emtricitabine / Tenofovir) risks & warnings »
        Coming soon.
        Pregnancy category
        TruvadaPrezista
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Can cause unusual dreams, or kidney or liver damage.
        • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
        • People on Truvada (Emtricitabine / Tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
        No specific kidneys and liver-related info.
        Sex
        • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
        No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        TruvadaPrezista
        • First-line treatment for preventing HIV infection in combination with other HIV medications.
        • Only has to be taken once a day.
        • Truvada (Emtricitabine / Tenofovir) prevents and treats HIV infection.
        • Used for preventing HIV infection in case you've been accidentally exposed or if you're in danger of being exposed.
        Coming soon.
        Downsides and risks
        TruvadaPrezista
        • Has to be taken at the same time every day or your body can become resistant to the medication.
        • Can't be taken on its own to treat HIV.
        • Can cause unusual dreams, or kidney or liver damage.
        • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
        • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
        Coming soon.
        Tips from our pharmacists for people taking the medication
        TruvadaPrezista
        • Since Truvada (Emtricitabine / Tenofovir) is only taken once a day, try taking it at the same time as your other HIV medications.
        • If being used for kids, the dose of Truvada (Emtricitabine / Tenofovir) will continue to change as they grow, so keep in touch with their doctor.
        • Keep an eye out for any new symptoms or side effects you may start to feel while taking Truvada (Emtricitabine / Tenofovir) and report them to your doctor.
        • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
        Coming soon.
        Learn more
        More about TruvadaSide effectsReviews & ratingsAlternativesFDA package insert
        More about PrezistaSide effectsFDA package insert