Compare Truvada vs. Sustiva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Truvada (emtricitabine / tenofovir)

Prescription only
Works with other medications to treat HIV infection, or works alone to prevent HIV infection.

Truvada (emtricitabine / tenofovir) is a versatile, first-choice HIV medication that is used in combination with other HIV medications to treat and prevent HIV infections.

6.8/ 7 average rating with 16 reviewsforTruvada
Works with other medicines to treat HIV infection.

Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.

Upsides
  • Contains two first-choice medications which can be used in combination with other drugs to treat HIV infection.
  • Truvada (emtricitabine / tenofovir) is also a first-choice option to be used for preventing HIV.
  • Take only once daily, with or without food.
  • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
  • Only taken once daily.
  • Sustiva (efavirenz) is available in combination tablets.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in children who are at least 3 months old.
Downsides
  • If you're taking Truvada (emtricitabine / tenofovir) to stop you from getting HIV, you should continue having safe sex since it won't protect you from other sexually transmitted infections.
  • If you're taking Truvada (emtricitabine / tenofovir) to stop you from getting HIV, you have to get blood tests every 3 months to check for overall health and to make sure you don't have HIV or other sexually transmitted infections.
  • People with poorly functioning kidneys shouldn't take Truvada (emtricitabine / tenofovir).
  • Can weaken your bones.
  • If you have HIV as well as Hepatitis B and stop taking Truvada (emtricitabine / tenofovir) suddenly, your hepatitis may get worse.
  • Not suggested for women who plan on becoming pregnant.
  • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
  • Cannot be taken alone for treatment of HIV.
Used for
  • HIV treatment
  • HIV prevention
Dosage forms
  • Pill
  • Pill
Price
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$1605.96
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$1007.22
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Reviews
16 
100%
think this treatment is worth it
94%
think this treatment works well
0%
think this treatment is a hassle

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Side effects
10possible side effects
  • Diarrhea
    9%
  • Nausea
    9%
  • Fatigue
    9%
  • Depression
    9%
  • Stuffy or runny nose
    8%
  • Flu or bronchitis
    8%
  • Dizziness
    8%
  • Rash event
    7%
  • Headache
    6%
  • Common cold
    5%
See more detailed side effects
8possible side effects
  • Skin rash
    16%
  • Diarrhea
    14%
  • Pain
    13%
  • Nausea
    10%
  • Dizziness
    9%
  • Itching
    9%
  • Fatigue
    8%
  • Headache
    8%
See more detailed side effects
Risks and warnings
  • Lactic acidosis | Enlarged, fatty liver

    Liver disease

    ...and 2 more risk factors

  • Worsening hepatitis B infection

    Hepatitis B Virus infection

  • Kidney damage

    History of kidney damage

    ...and 1 more risk factors

  • Bone loss/osteoporosis

    History of bone fractures

    ...and 1 more risk factors

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

  • Drug resistance while using pre-exposure prophylaxis (PrEP)

    Undiscovered HIV infection while on PrEP

See more detailed risks and warnings
  • Central nervous system (CNS) effects

    Starting Sustiva (efavirenz) for the first few weeks.

    ...and 1 more risk factors

  • Fat redistribution

    HIV treatment

  • Liver damage

    History of liver damage

    ...and 1 more risk factors

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

  • Psychiatric effects

    History of mental illness

    ...and 1 more risk factors

  • Rash

    History of severe skin reactions

    ...and 1 more risk factors

See more detailed risks and warnings