Compare Tylenol Cold Multi-Symptom Daytime vs. Theraflu Daytime Severe Cold And Cough

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves cold and flu symptoms.

Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Relieves cold and flu symptoms.

Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for treating multiple cold and flu symptoms, but it's more medicine than you need if you only have one symptom.

Upsides
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
  • Pill
  • Liquid
  • Powder
  • Powder
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Side effects
The Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver damage
    • Taking with alcohol
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Chronic cough from an infection
    • History of chronic obstructive pulmonary disease (COPD)
    • History of smoking
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 3 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • Chronic cough from an infection
    • History of chronic obstructive pulmonary disease (COPD)
    • History of smoking
  • High blood pressure
    • History of high blood pressure
    • Taking MAO inhibitors
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Brain damage from too much phenylalanine
    • History of phenylketonuria (PKU)
  • Harm to unborn babies
    • Women of childbearing age
See more detailed risks and warnings