Compare Tylenol Sinus vs. Advil Cold and Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Sinus
(Acetaminophen / Phenylephrine)

Advil Cold And Sinus
(Ibuprofen / Pseudoephedrine)

Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.9226190476190474Tylenol Sinus
Reviews for Tylenol Sinus (Acetaminophen / Phenylephrine)
74%
of people say Tylenol Sinus (Acetaminophen / Phenylephrine) is worth it
31%
say it works well
5%
say it's a big hassle
Reviews for Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)
75%
+1% vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
34%
+3% vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
6%
1% vs. Tylenol Sinus (Acetaminophen / Phenylephrine)
Side effects
Tylenol SinusAdvil Cold and Sinus

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »

We haven’t found good data for Advil Cold and Sinus side effects.

FDA side effect reports for Advil Cold and Sinus »
How it works
Tylenol SinusAdvil Cold and Sinus
Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Tylenol SinusAdvil Cold and Sinus
Pain reliever
APAP
DecongestantOver-the-counter
Pain reliever
NSAID
DecongestantOver-the-counter
Available as
Tylenol SinusAdvil Cold and Sinus
  • Pill
  • Pill
Used for (click to learn more)
Tylenol SinusAdvil Cold and Sinus
Risk factors for serious side effects
Tylenol SinusAdvil Cold and Sinus
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • Women of childbearing age
Detailed Tylenol Sinus (Acetaminophen / Phenylephrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • History of high blood pressure
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) risks & warnings »
Pregnancy category
Tylenol SinusAdvil Cold and Sinus
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) for any amount of time.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Tylenol SinusAdvil Cold and Sinus
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
Downsides and risks
Tylenol SinusAdvil Cold and Sinus
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
Tips from our pharmacists for people taking the medication
Tylenol SinusAdvil Cold and Sinus
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in 30 minutes.
  • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Take it after eating to avoid getting an upset stomach.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
  • Talk to your doctor if symptoms don't get better in 1 week.
  • Starts working in 30 minutes.
Learn more
More about Tylenol SinusSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil Cold and SinusSide effectsReviews & ratingsAlternativesFDA package insert