Compare Tylenol Sinus vs. Allegra D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Sinus
(acetaminophen / phenylephrine)

Allegra D
(pseudoephedrine / fexofenadine)

Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.92Tylenol Sinus
Reviews for Tylenol Sinus
74%
of people (All ages) say Tylenol Sinus is worth it
31%
say it works well
5%
say it's a big hassle
1176 reviews
Have you used Tylenol Sinus (acetaminophen / phenylephrine)?
Worth itNot sureNot worth it

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Have you used Allegra D (pseudoephedrine / fexofenadine)?
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Side effects
Tylenol SinusAllegra D

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »
  • Headache 3%
  • Back pain 2%
  • Sleep difficulty 13%
  • Nausea 7%
  • Adverse effects 4%
  • Indigestion 3%
  • Dry mouth 3%
  • Dizziness 2%
  • Agitation 2%
More Allegra D side effects »
How it works
Tylenol SinusAllegra D
Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Tylenol SinusAllegra D
Over-the-counterPrescription or OTC
Available as
Tylenol SinusAllegra D
  • Pill
  • Extended release
Used for
Tylenol SinusAllegra D
Risk factors for serious side effects
Tylenol SinusAllegra D
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Sinus (acetaminophen / phenylephrine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
Detailed Allegra D (pseudoephedrine / fexofenadine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
Tylenol SinusAllegra D
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.
Pain
Tylenol SinusAllegra D
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
No pain related info.
Sleep
Tylenol SinusAllegra D
No sleep related info.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
Upsides and benefits
Tylenol SinusAllegra D
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • Available without a prescription in the drugstore.
  • It has two medications that work in different ways to help relieve nasal symptoms.
  • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
  • The decongestant (pseudoephedrine) is very good at relieving congestion.
Downsides and risks
Tylenol SinusAllegra D
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • Has more side effects than Allegra since it has pseudoephedrine in it.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
Tips from our pharmacists for people taking the medication
Tylenol SinusAllegra D
  • Starts working in 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • It works best if you have nasal congestion and a runny nose.
  • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
  • Shouldn't be used in kids younger than 12 years old.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • Can cause dizziness, headache, or a fast heartbeat.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
Learn more
More about Tylenol SinusSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Sinus (acetaminophen / phenylephrine)?
Worth itNot sureNot worth it
More about Allegra DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Allegra D (pseudoephedrine / fexofenadine)?
Worth itNot sureNot worth it