Compare Tylenol vs. Celebrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(acetaminophen)

Celebrex
(celecoxib)

Relieves pain and fever. Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.01Tylenol
Reviews for Tylenol
77%
of people (All ages) say Tylenol is worth it
37%
say it works well
3%
say it's a big hassle
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Reviews for Celebrex
57%
+20% better vs. Tylenol
38%
-1% worse vs. Tylenol
14%
+11% better vs. Tylenol
550 reviews
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
Side effects
TylenolCelebrex

The Tylenol FDA package insert doesn’t have numbers about how common side effects are.

More about Tylenol side effects »

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
How it works
TylenolCelebrex
Tylenol Regular Strength (acetaminophen) is an analgesic. It relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause both pain and fever.Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
TylenolCelebrex
Over-the-counterPrescription only
Available as
TylenolCelebrex
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
  • Pill
Used for
TylenolCelebrex
Risk factors for serious side effects
TylenolCelebrex
  • Medication administering errors
  • Injection formulation
  • Exceeding the recommended maximum daily limits
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
Detailed Celebrex (celecoxib) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
TylenolCelebrex
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
No alcohol related info.
Food
TylenolCelebrex
No food related info.
  • Take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
TylenolCelebrex
  • Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Signs of liver problems may include dark urine, feeling tired, upset stomach or stomach pain, or yellow skin or eyes. If you notice any of these symptoms, call your doctor immediately. Avoid drinking alcohol when taking Tylenol Regular Strength (acetaminophen). Avoid using Tylenol Regular Strength (acetaminophen) if you have existing liver problems since it can cause further damage.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
Pain
TylenolCelebrex
  • Works well to relieve pain and fevers.
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
Upsides and benefits
TylenolCelebrex
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
Downsides and risks
TylenolCelebrex
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
Tips from our pharmacists for people taking the medication
TylenolCelebrex
  • Tylenol Regular Strength (acetaminophen) starts working within one hour.
  • Taking too much of Tylenol Regular Strength (acetaminophen) can cause liver failure and death. Don't take more than what's recommended on the package insert.
  • Acetaminophen is found in many over-the-counter and prescription products. Make sure the total amount of acetaminophen you take does not exceed 3,000 mg per day and check with your pharmacist to make sure you're not taking too much.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it