Compare Tylenol vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(Acetaminophen)

Coumadin
(Warfarin)

Relieves pain and fever. Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain well, but it doesn't lower inflammation and swelling.Prevents blood clots. Coumadin (Warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.
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Reviews & ratings
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5.01Tylenol
Reviews for Tylenol Regular Strength (Acetaminophen)
77%
of people (All ages) say Tylenol Regular Strength (Acetaminophen) is worth it
37%
say it works well
3%
say it's a big hassle
1002 reviews
Have you used Tylenol Regular Strength (Acetaminophen)?
Worth itNot sureNot worth it
Reviews for Coumadin (Warfarin)
61%
16% vs. Tylenol Regular Strength (Acetaminophen)
54%
+17% vs. Tylenol Regular Strength (Acetaminophen)
21%
18% vs. Tylenol Regular Strength (Acetaminophen)
513 reviews
Have you used Coumadin (Warfarin)?
Worth itNot sureNot worth it
Side effects
TylenolCoumadin

We haven’t found good data for Tylenol side effects.

FDA side effect reports for Tylenol »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
TylenolCoumadin
Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain, but doesn't lower inflammation and swelling.Coumadin (Warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.
Type of medication
TylenolCoumadin
Pain reliever
Acetaminophen (APAP)
Over-the-counter
Anticoagulant
Vitamin K antagonist
Prescription only
Available as
TylenolCoumadin
  • Pill
  • Extended release tablet
  • Chewable tablet
  • Dissolving tablet
  • Gelcap
  • Liquid
  • Suppository
  • Pill
Used for (click to learn more)
TylenolCoumadin
Risk factors for serious side effects
TylenolCoumadin
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
Detailed risks & warnings »
  • Coumadin (Warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
Detailed risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
TylenolCoumadin
No interactions related info.
  • A lot of other drugs and supplements interact with Coumadin (Warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
  • Coumadin (Warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
Alcohol
TylenolCoumadin
  • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
  • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
No alcohol related info.
Kidneys and liver
TylenolCoumadin
  • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.
Pain
TylenolCoumadin
  • Works well to relieve pain and fevers.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
No pain related info.
Upsides and benefits
TylenolCoumadin
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (Acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin, ibuprofen, and naproxen.
  • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Coumadin (Warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (Warfarin), your doctor can give you another drug that reverses Coumadin (Warfarin)'s effects.
  • Coumadin (Warfarin) comes in numerous strengths.
  • Coumadin (Warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
Downsides and risks
TylenolCoumadin
  • Tylenol Regular Strength (Acetaminophen) doesn't treat pain as well as other medications like ibuprofen and naproxen.
  • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (Warfarin) is working correctly.
  • Your daily dose of Coumadin (Warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (Warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Tips from our pharmacists for people taking the medication
TylenolCoumadin
  • Starts working in one hour.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take. Adults should never take more than 3,000 milligrams (mg) in a single day.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
  • Take Coumadin (Warfarin) exactly as your doctor tells you.
  • Once you're taking Coumadin (Warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
  • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (Warfarin) in case you have a medical emergency.
  • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (Warfarin).
  • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (Acetaminophen)?
Worth itNot sureNot worth it
More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Coumadin (Warfarin)?
Worth itNot sureNot worth it