Compare Tylenol vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(acetaminophen)

Coumadin
(warfarin)

Relieves pain and fever. Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.
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Coupons for Tylenol
Best available price for 30 (20mg) tablets of simvastatin
Coupons for Coumadin
Best available price for 30 (5mg) tablets of warfarin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.01Tylenol
Reviews for Tylenol
77%
of people (All ages) say Tylenol is worth it
37%
say it works well
3%
say it's a big hassle
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Reviews for Coumadin
61%
+16% better vs. Tylenol
54%
-17% worse vs. Tylenol
21%
+18% better vs. Tylenol
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
Side effects
TylenolCoumadin

The Tylenol FDA package insert doesn’t have numbers about how common side effects are.

More about Tylenol side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
TylenolCoumadin
Tylenol Regular Strength (acetaminophen) is an analgesic. It relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause both pain and fever.Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.
Type of medication
TylenolCoumadin
Over-the-counterPrescription only
Available as
TylenolCoumadin
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
  • Pill
Used for
TylenolCoumadin
Risk factors for serious side effects
TylenolCoumadin
  • Medication administering errors
  • Injection formulation
  • Exceeding the recommended maximum daily limits
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
Detailed Coumadin (warfarin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
TylenolCoumadin
No interactions related info.
  • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Alcohol
TylenolCoumadin
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
No alcohol related info.
Kidneys and liver
TylenolCoumadin
  • Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Signs of liver problems may include dark urine, feeling tired, upset stomach or stomach pain, or yellow skin or eyes. If you notice any of these symptoms, call your doctor immediately. Avoid drinking alcohol when taking Tylenol Regular Strength (acetaminophen). Avoid using Tylenol Regular Strength (acetaminophen) if you have existing liver problems since it can cause further damage.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
No kidneys and liver related info.
Pain
TylenolCoumadin
  • Works well to relieve pain and fevers.
No pain related info.
Upsides and benefits
TylenolCoumadin
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
Downsides and risks
TylenolCoumadin
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
Tips from our pharmacists for people taking the medication
TylenolCoumadin
  • Tylenol Regular Strength (acetaminophen) starts working within one hour.
  • Taking too much of Tylenol Regular Strength (acetaminophen) can cause liver failure and death. Don't take more than what's recommended on the package insert.
  • Acetaminophen is found in many over-the-counter and prescription products. Make sure the total amount of acetaminophen you take does not exceed 3,000 mg per day and check with your pharmacist to make sure you're not taking too much.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
  • Take Coumadin (warfarin) exactly as your doctor tells you.
  • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
  • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
  • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
  • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it