Compare Tylenol vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(Acetaminophen)

Coumadin
(Warfarin)

Relieves pain and fever. Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain well, but it doesn't lower inflammation and swelling.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.
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Reviews & ratings
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5.019019019019019Tylenol
Reviews for Tylenol Regular Strength (Acetaminophen)
77%
of people say Tylenol Regular Strength (Acetaminophen) is worth it
37%
say it works well
3%
say it's a big hassle
Reviews for Coumadin (Warfarin)
61%
16% vs. Tylenol Regular Strength (Acetaminophen)
54%
+17% vs. Tylenol Regular Strength (Acetaminophen)
21%
18% vs. Tylenol Regular Strength (Acetaminophen)
Side effects
TylenolCoumadin

We haven’t found good data for Tylenol side effects.

FDA side effect reports for Tylenol »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
TylenolCoumadin
Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain, but doesn't lower inflammation and swelling.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.
Type of medication
TylenolCoumadin
Pain reliever
Acetaminophen (APAP)
Over-the-counter
Anticoagulant
Vitamin K antagonist
Prescription only
Available as
TylenolCoumadin
  • Pill
  • Extended release tablet
  • Chewable tablet
  • Dissolving tablet
  • Gelcap
  • Liquid
  • Suppository
  • Pill
Used for (click to learn more)
TylenolCoumadin
Risk factors for serious side effects
TylenolCoumadin
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
Detailed Tylenol Regular Strength (Acetaminophen) risks & warnings »
  • Dose too high
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Kidney or liver problems
  • Drug interactions
  • Change in lifestyle or diet
  • Illnesses
  • Alcohol
  • Certain genetic makeup
    • Women of childbearing age
    Detailed Coumadin (Warfarin) risks & warnings »
    Pregnancy category
    TylenolCoumadin
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    Alcohol
    • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
    • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    Food
    No specific food-related info.
    • Eat foods containing consistent amounts of Vitamin K.
    Kidneys and liver
    • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    TylenolCoumadin
    • Works well to relieve pain and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Tylenol Regular Strength (Acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin, ibuprofen, and naproxen.
    • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
    • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
    • Has an antidote, Vitamin K, in case of a major accidental bleeding.
    • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
    • It's dirt cheap.
    Downsides and risks
    TylenolCoumadin
    • Tylenol Regular Strength (Acetaminophen) doesn't treat pain as well as other medications like ibuprofen and naproxen.
    • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
    • Raises your risk of bleeding and bruising.
    • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    Tips from our pharmacists for people taking the medication
    TylenolCoumadin
    • Starts working in one hour.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Follow age-specific dosing instructions on how much to take. Adults should never take more than 3,000 milligrams (mg) in a single day.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • The amount you need depends on your diet, other medical problems, and genes.
    • Take it exactly as instructed.
    • Can raise your risk of bleeding or bruising.
    • Requires regular blood tests to get your dose right.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Eat foods containing consistent amounts of Vitamin K.
    • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
    • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
    Learn more
    More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
    More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert