Compare Tylenol vs. Morphine sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(Acetaminophen)

Ms Contin
(Morphine Sulfate)

Relieves pain and fever. Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain well, but it doesn't lower inflammation and swelling.Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.019019019019019Tylenol
Reviews for Tylenol Regular Strength (Acetaminophen)
77%
of people say Tylenol Regular Strength (Acetaminophen) is worth it
37%
say it works well
3%
say it's a big hassle
Reviews for Ms Contin (Morphine Sulfate)
55%
22% vs. Tylenol Regular Strength (Acetaminophen)
43%
+6% vs. Tylenol Regular Strength (Acetaminophen)
20%
17% vs. Tylenol Regular Strength (Acetaminophen)
Side effects
TylenolMorphine sulfate

We haven’t found good data for Tylenol side effects.

FDA side effect reports for Tylenol »

The Morphine sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine sulfate side effects »
How it works
TylenolMorphine sulfate
Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain, but doesn't lower inflammation and swelling.Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.
Type of medication
TylenolMorphine sulfate
Pain reliever
Acetaminophen (APAP)
Over-the-counter
Pain reliever
Opioid
Prescription only
Available as
TylenolMorphine sulfate
  • Pill
  • Extended release tablet
  • Chewable tablet
  • Dissolving tablet
  • Gelcap
  • Liquid
  • Suppository
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Used for (click to learn more)
TylenolMorphine sulfate
Risk factors for serious side effects
TylenolMorphine sulfate
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
Detailed Tylenol Regular Strength (Acetaminophen) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
Detailed Ms Contin (Morphine Sulfate) risks & warnings »
Pregnancy category
TylenolMorphine sulfate
Alcohol
  • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
  • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
No specific alcohol-related info.
Food
No specific food-related info.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
  • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Can make you dizzy or drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
TylenolMorphine sulfate
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (Acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin, ibuprofen, and naproxen.
  • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides and risks
TylenolMorphine sulfate
  • Tylenol Regular Strength (Acetaminophen) doesn't treat pain as well as other medications like ibuprofen and naproxen.
  • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Tips from our pharmacists for people taking the medication
TylenolMorphine sulfate
  • Starts working in one hour.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take. Adults should never take more than 3,000 milligrams (mg) in a single day.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
More about Morphine sulfateSide effectsReviews & ratingsAlternativesFDA package insert