Compare Tylenol vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(acetaminophen)

Ms Contin
(morphine sulfate)

Relieves pain and fever. Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.
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Coupons for Tylenol
Best available price for 30 (20mg) tablets of simvastatin
Coupons for Morphine Sulfate
Best available price for 120 (15mg) tablets of morphine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.01Tylenol
Reviews for Tylenol
77%
of people (All ages) say Tylenol is worth it
37%
say it works well
3%
say it's a big hassle
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Reviews for Morphine Sulfate
55%
+22% better vs. Tylenol
43%
-6% worse vs. Tylenol
20%
+17% better vs. Tylenol
541 reviews
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it
Side effects
TylenolMorphine Sulfate

The Tylenol FDA package insert doesn’t have numbers about how common side effects are.

More about Tylenol side effects »

The Morphine Sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine Sulfate side effects »
How it works
TylenolMorphine Sulfate
Tylenol Regular Strength (acetaminophen) is an analgesic. It relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause both pain and fever.Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.
Type of medication
TylenolMorphine Sulfate
Over-the-counterPrescription only
Available as
TylenolMorphine Sulfate
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Used for
TylenolMorphine Sulfate
Risk factors for serious side effects
TylenolMorphine Sulfate
  • Medication administering errors
  • Injection formulation
  • Exceeding the recommended maximum daily limits
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Ms Contin (morphine sulfate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
TylenolMorphine Sulfate
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
No alcohol related info.
Food
TylenolMorphine Sulfate
No food related info.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
TylenolMorphine Sulfate
  • Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Signs of liver problems may include dark urine, feeling tired, upset stomach or stomach pain, or yellow skin or eyes. If you notice any of these symptoms, call your doctor immediately. Avoid drinking alcohol when taking Tylenol Regular Strength (acetaminophen). Avoid using Tylenol Regular Strength (acetaminophen) if you have existing liver problems since it can cause further damage.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
No kidneys and liver related info.
Pain
TylenolMorphine Sulfate
  • Works well to relieve pain and fevers.
  • Good for chronic pain that requires around-the-clock relief.
  • Doesn't work for as-needed or quick pain relief.
Sleep
TylenolMorphine Sulfate
No sleep related info.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
TylenolMorphine Sulfate
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides and risks
TylenolMorphine Sulfate
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Tips from our pharmacists for people taking the medication
TylenolMorphine Sulfate
  • Tylenol Regular Strength (acetaminophen) starts working within one hour.
  • Taking too much of Tylenol Regular Strength (acetaminophen) can cause liver failure and death. Don't take more than what's recommended on the package insert.
  • Acetaminophen is found in many over-the-counter and prescription products. Make sure the total amount of acetaminophen you take does not exceed 3,000 mg per day and check with your pharmacist to make sure you're not taking too much.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
More about Morphine SulfateSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it