Compare Tylenol vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves pain and fever.

Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.

3.7/ 5 average rating with 1002 reviewsforTylenol
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

3.8/ 5 average rating with 1399 reviewsforPercocet
Upsides
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
  • Pill
  • Oral solution
Price
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Reviews
1002 reviews so far
77%
saidit'sworth it
37%
saiditworked well
3%
saidit'sa big hassle

Have you used Tylenol Regular Strength (acetaminophen)?

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1399 reviews so far
70%
saidit'sworth it
49%
saiditworked well
15%
saidit'sa big hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
The Tylenol Regular Strength (acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Accidental overdose and death
    • Medication administering errors
    • Injection formulation
    • Exceeding the recommended maximum daily limits
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
See more detailed risks and warnings
  • Death from liver failure
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
  • Death from lack of oxygen to the body (respiratory depression)
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Tolerance and dependence
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Neonatal withdrawal syndrome
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Death from overdose (extended-release tablet)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
  • Severe allergic reactions
  • Low blood pressure
    • Age 65 years or older
    • Circulation problems
See more detailed risks and warnings