Compare Tylenol vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(acetaminophen)

Plavix
(clopidogrel)

Relieves pain and fever. Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.Prevents blood clots. Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.01Tylenol
Reviews for Tylenol
77%
of people (All ages) say Tylenol is worth it
37%
say it works well
3%
say it's a big hassle
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Reviews for Plavix
59%
+18% better vs. Tylenol
49%
-12% worse vs. Tylenol
16%
+13% better vs. Tylenol
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Side effects
TylenolPlavix

The Tylenol FDA package insert doesn’t have numbers about how common side effects are.

More about Tylenol side effects »
  • Minor bleeding 3%
  • Major bleeding 1%
More Plavix side effects »
How it works
TylenolPlavix
Tylenol Regular Strength (acetaminophen) is an analgesic. It relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause both pain and fever.Plavix (clopidogrel) is an antiplatelet blood thinner. It stops platelets in your blood from clumping together which makes it harder for them to form clots.
Type of medication
TylenolPlavix
Over-the-counterPrescription only
Available as
TylenolPlavix
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
  • Pill
Used for
TylenolPlavix
Risk factors for serious side effects
TylenolPlavix
  • Medication administering errors
  • Injection formulation
  • Exceeding the recommended maximum daily limits
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
  • Taking Prilosec or Nexium
  • People with certain genes that make Plavix (clopidogrel) less effective
  • History of stomach bleeding
  • Taking other medicines that increase the levels of Plavix (clopidogrel) in your body
  • Taking other blood thinners or medicines that increase the risk of bleeding
Detailed Plavix (clopidogrel) risks & warnings »
Pregnancy
Alcohol
TylenolPlavix
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
No alcohol related info.
Kidneys and liver
TylenolPlavix
  • Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Signs of liver problems may include dark urine, feeling tired, upset stomach or stomach pain, or yellow skin or eyes. If you notice any of these symptoms, call your doctor immediately. Avoid drinking alcohol when taking Tylenol Regular Strength (acetaminophen). Avoid using Tylenol Regular Strength (acetaminophen) if you have existing liver problems since it can cause further damage.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
No kidneys and liver related info.
Pain
TylenolPlavix
  • Works well to relieve pain and fevers.
No pain related info.
Upsides and benefits
TylenolPlavix
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
Downsides and risks
TylenolPlavix
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
Tips from our pharmacists for people taking the medication
TylenolPlavix
  • Tylenol Regular Strength (acetaminophen) starts working within one hour.
  • Taking too much of Tylenol Regular Strength (acetaminophen) can cause liver failure and death. Don't take more than what's recommended on the package insert.
  • Acetaminophen is found in many over-the-counter and prescription products. Make sure the total amount of acetaminophen you take does not exceed 3,000 mg per day and check with your pharmacist to make sure you're not taking too much.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Thins your blood to prevent clots from forming or getting bigger.
  • Can raise your risk of bleeding or bruising.
  • Take this medicine exactly as told by your doctor.
  • Plavix (clopidogrel) may not be safe to be taken together with some medicines and over-the-counter supplements. Don't start any new medicine without first speaking with your doctor or pharmacist.
  • Let your doctor know right away if you experience a fever, weakness, or unusual bleeding and bruising.
  • You should stop taking Plavix (clopidogrel) at least 5 days before any major surgeries to lower your chances of bleeding.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it