Compare Tylenol vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tylenol Regular Strength
(acetaminophen)

Plavix
(clopidogrel)

Relieves pain and fever. Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain well, but it doesn't lower inflammation and swelling.Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.
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Coupons for Tylenol
Best available price for 30 (325mg) tablets of acetaminophen
Coupons for Plavix
Best available price for 30 (75mg) tablets of clopidogrel
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.01Tylenol
Reviews for Tylenol Regular Strength (acetaminophen)
77%
of people (All ages) say Tylenol Regular Strength (acetaminophen) is worth it
37%
say it works well
3%
say it's a big hassle
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Reviews for Plavix (clopidogrel)
59%
-18% worse vs. Tylenol Regular Strength (acetaminophen)
49%
+12% better vs. Tylenol Regular Strength (acetaminophen)
16%
-13% worse vs. Tylenol Regular Strength (acetaminophen)
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Side effects
TylenolPlavix

We haven’t found good data for Tylenol side effects.

FDA side effect reports for Tylenol »
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
How it works
TylenolPlavix
Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain, but doesn't lower inflammation and swelling.Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.
Type of medication
TylenolPlavix
Over-the-counter
Prescription only
Available as
TylenolPlavix
  • Pill
  • Extended release tablet
  • Chewable tablet
  • Dissolving tablet
  • Gelcap
  • Liquid
  • Suppository
  • Pill
Used for
TylenolPlavix
Risk factors for serious side effects
TylenolPlavix
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
Detailed Plavix (clopidogrel) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
TylenolPlavix
No interactions related info.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
Alcohol
TylenolPlavix
  • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
  • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
No alcohol related info.
Kidneys and liver
TylenolPlavix
  • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.
Pain
TylenolPlavix
  • Works well to relieve pain and fevers.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
No pain related info.
Upsides and benefits
TylenolPlavix
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (Acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin, ibuprofen, and naproxen.
  • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
  • Studies have shown clopidogrel lowers your risk of death or further heart complications.
Downsides and risks
TylenolPlavix
  • Tylenol Regular Strength (Acetaminophen) doesn't treat pain as well as other medications like ibuprofen and naproxen.
  • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
  • Raises your risk of bleeding and bruising.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Doesn't work well for people with certain genetic variations.
Tips from our pharmacists for people taking the medication
TylenolPlavix
  • Starts working in one hour.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take. Adults should never take more than 3,000 milligrams (mg) in a single day.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
  • Can raise your risk of bleeding or bruising.
  • Take it exactly as instructed.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
  • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
Learn more
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it