Compare Uloric vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Uloric
(febuxostat)

Zyloprim
(allopurinol)

Prevents gout attacks. Uloric (Febuxostat) is a once a day medication for chronic gout, but it takes a few weeks to kick in.Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
Reviews & ratings
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Have you used Uloric (febuxostat)?
Worth itNot sureNot worth it
Reviews for Allopurinol
71%
-21% worse vs. Uloric
52%
+15% better vs. Uloric
5%
-12% worse vs. Uloric
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it
Side effects
UloricAllopurinol
  • Liver function abnormalities 6%
  • Rash 1%
More Uloric side effects »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
How it works
UloricAllopurinol
Uloric (Febuxostat) is an antigout xanthine oxidase inhibitor. It decreases the build up of uric acid, the enzyme that causes gout.Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.
Type of medication
UloricAllopurinol
Prescription onlyPrescription only
Available as
UloricAllopurinol
  • Pill
  • Pill
  • Injection
Used for
UloricAllopurinol
Risk factors for serious side effects
UloricAllopurinol
    Detailed Uloric (febuxostat) risks & warnings »
    • History of kidney stones
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
    Detailed Zyloprim (allopurinol) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    UloricAllopurinol
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    No alcohol related info.
    Food
    UloricAllopurinol
    No food related info.
    • Take with food or milk to prevent an upset stomach.
    Kidneys and liver
    UloricAllopurinol
    • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
    • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
    Sleep
    UloricAllopurinol
    No sleep related info.
    • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
    Upsides and benefits
    UloricAllopurinol
    • In one clinical trial, Uloric (Febuxostat) was shown to decrease uric acid to normal levels in over half of the people taking it. It worked better than Zyloprim (allopurinol).
    • You only need to take Uloric (Febuxostat) once a day.
    • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
    • Zyloprim (allopurinol) works well to lower uric acid in the body.
    • It is available as a generic medication.
    Downsides and risks
    UloricAllopurinol
    • Can increase the amount of gout attacks in the first few weeks.
    • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
    • While taking Uloric (Febuxostat), you'll have to get your blood checked often.
    • Doesn't come in a generic version.
    • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
    • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
    • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
    Tips from our pharmacists for people taking the medication
    UloricAllopurinol
    • In the first few months of taking Uloric (Febuxostat), you can still have gout attacks. Don’t give up since it takes a while to fully work. Your doctor can give you another medication to help until it's working well.
    • Take Uloric (Febuxostat) at the same time everyday, with or without food.
    • To make sure Uloric (Febuxostat) is working, have your blood checked often.
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    • Drink plenty of water while taking Zyloprim (allopurinol).
    • Take with food or milk to prevent an upset stomach.
    • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
    • Your doctor can run blood tests to make sure the medication is working as it should.
    • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
    • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
    Learn more
    More about UloricSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Uloric (febuxostat)?
    Worth itNot sureNot worth it
    More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zyloprim (allopurinol)?
    Worth itNot sureNot worth it