Compare Unisom vs. Benadryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Unisom Sleeptabs (Doxylamine)

Prescription or OTC

Benadryl (Diphenhydramine)

Prescription or OTC
Treats allergy symptoms and helps you sleep.

Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.

4.5/ 7 average rating with 585 reviewsforUnisom
Treats allergy symptoms and helps you sleep.

Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.

5.6/ 7 average rating with 294 reviewsforBenadryl
Upsides
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
Downsides
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Oral solution
  • Cream, gel, or ointment
No pricing information available
No pricing information available
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Reviews
585 
58%
think this treatment is worth it
32%
think this treatment works well
11%
think this treatment is a hassle

Have you used Unisom Sleeptabs (Doxylamine)?

Leave a review
294 
86%
think this treatment is worth it
59%
think this treatment works well
8%
think this treatment is a hassle

Have you used Benadryl (Diphenhydramine)?

Leave a review
Side effects
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
The Benadryl (Diphenhydramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Overdosage

    Using other drugs with similar ingredients

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Hyperactivity

    Children age 6 years or younger

  • Trouble urinating

    Enlarged prostate

    ...and 1 more risk factors

  • Vision changes

    Glaucoma

  • Breastfeeding

    Nursing mothers

See more detailed risks and warnings
  • Overdose

    Using other drugs with the same ingredients

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Hyperactivity

    Children age 6 years and younger

  • Trouble urinating

    Enlarged prostate

    ...and 1 more risk factors

  • Vision changes

    Glaucoma

  • Breastfeeding

    Nursing mothers

See more detailed risks and warnings