Compare Unisom vs. Lunesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Unisom Sleeptabs
(doxylamine)

Lunesta
(eszopiclone)

Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.
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Coupons for Unisom
Best available price for 30 (50mg) capsules of unisom
Coupons for Lunesta
Best available price for 30 (3mg) tablets of lunesta
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.45Unisom
Reviews for Unisom
58%
of people (All ages) say Unisom is worth it
32%
say it works well
11%
say it's a big hassle
585 reviews
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it
Reviews for Lunesta
55%
+3% better vs. Unisom
36%
-4% worse vs. Unisom
17%
+6% better vs. Unisom
592 reviews
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it
Side effects
UnisomLunesta

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »
How it works
UnisomLunesta
Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.
Type of medication
UnisomLunesta
Prescription or OTCPrescription only
Available as
UnisomLunesta
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
Used for
UnisomLunesta
Risk factors for serious side effects
UnisomLunesta
  • Using other drugs with similar ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years or younger
Detailed Unisom Sleeptabs (doxylamine) risks & warnings »
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Lunesta (eszopiclone) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
UnisomLunesta
  • Don't take it with alcohol or other drugs that make you sleepy.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • Avoid alcohol and drugs.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
Sleep
UnisomLunesta
  • Not habit-forming like other sleep aids can be.
  • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
  • Only take it if you have time to sleep for at least 7 hours.
  • Can cause headache, drowsiness, and dizziness.
  • Effective at helping people fall asleep faster and sleep longer.
Upsides and benefits
UnisomLunesta
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
Downsides and risks
UnisomLunesta
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
Tips from our pharmacists for people taking the medication
UnisomLunesta
  • Starts working in 30 minutes.
  • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 7 hours.
  • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Can cause headache, drowsiness, and dizziness.
  • Can cause sleep-walking, sleep-driving, and sleep-eating.
  • Works best if taken without food.
  • Avoid alcohol and drugs.
  • Withdrawal symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
Learn more
More about UnisomSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it
More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it