Compare Unisom vs. Lunesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Unisom Sleeptabs (Doxylamine)

Prescription or OTC

Lunesta (Eszopiclone)

Prescription only
Treats allergy symptoms and helps you sleep.

Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.

4.5/ 7 average rating with 585 reviewsforUnisom
Helps you sleep.

Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.

4.5/ 7 average rating with 592 reviewsforLunesta
Upsides
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
Downsides
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
Price
No pricing information available
Lowest price near you
$22.82
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Reviews
585 
58%
think this treatment is worth it
32%
think this treatment works well
11%
think this treatment is a hassle

Have you used Unisom Sleeptabs (Doxylamine)?

Leave a review
592 
55%
think this treatment is worth it
36%
think this treatment works well
17%
think this treatment is a hassle

Have you used Lunesta (Eszopiclone)?

Leave a review
Side effects
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
    15%
  • Unpleasant Taste
    8%
  • Dyspepsia
    6%
  • Pain
    4%
  • Diarrhea
    4%
  • Pruritus
    4%
  • Dry Mouth
    3%
  • Abnormal Dreams
    3%
  • Neuralgia
    3%
  • Urinary Tract Infection
    3%
See more detailed side effects
Risks and warnings
  • Overdosage

    Using other drugs with similar ingredients

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Hyperactivity

    Children age 6 years or younger

  • Trouble urinating

    Enlarged prostate

    ...and 1 more risk factors

  • Vision changes

    Glaucoma

  • Breastfeeding

    Nursing mothers

See more detailed risks and warnings
  • Dependence and withdrawal

    Continuous use for 2 weeks or more

  • Driving impairment

    Alcohol

    ...and 2 more risk factors

  • Abnormal thoughts

    Undiagnosed psychiatric conditions

  • Sleep driving

    Taking with alcohol or drugs that acts in the brain

  • Risk of falls and injury

    Elderly

    ...and 4 more risk factors

  • Risk to fetus

    Women of childbearing age

    ...and 1 more risk factors

See more detailed risks and warnings