Compare Unisom vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Unisom Sleeptabs (Doxylamine)

Prescription or OTC

Mucinex (Guaifenesin)

Over-the-counter
Treats allergy symptoms and helps you sleep.

Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.

4.5/ 7 average rating with 585 reviewsforUnisom
Breaks up mucus that causes cough.

Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.

5.2/ 7 average rating with 902 reviewsforMucinex
Upsides
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
  • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
  • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
  • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
  • Available in liquid and tablet forms.
  • Mucinex (Guaifenesin) is alcohol- and sugar-free.
Downsides
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
  • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
  • You need to drink a lot of fluids while taking this medication or it won't work as well.
  • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
  • Can cause nausea, headache, and an upset stomach.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
  • Liquid
No pricing information available
No pricing information available
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Reviews
585 
58%
think this treatment is worth it
32%
think this treatment works well
11%
think this treatment is a hassle

Have you used Unisom Sleeptabs (Doxylamine)?

Leave a review
902 
78%
think this treatment is worth it
47%
think this treatment works well
7%
think this treatment is a hassle

Have you used Mucinex (Guaifenesin)?

Leave a review
Side effects
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
The Mucinex (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Overdosage

    Using other drugs with similar ingredients

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Hyperactivity

    Children age 6 years or younger

  • Trouble urinating

    Enlarged prostate

    ...and 1 more risk factors

  • Vision changes

    Glaucoma

  • Breastfeeding

    Nursing mothers

See more detailed risks and warnings