Compare Unisom vs. Mucinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Unisom Sleeptabs
(Doxylamine)

Mucinex
(Guaifenesin)

Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.428076256499134Unisom
Reviews for Unisom Sleeptabs (Doxylamine)
58%
of people say Unisom Sleeptabs (Doxylamine) is worth it
32%
say it works well
11%
say it's a big hassle
Reviews for Mucinex (Guaifenesin)
78%
+20% vs. Unisom Sleeptabs (Doxylamine)
47%
+15% vs. Unisom Sleeptabs (Doxylamine)
7%
+4% vs. Unisom Sleeptabs (Doxylamine)
Side effects
UnisomMucinex

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »
How it works
UnisomMucinex
Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
UnisomMucinex
Antihistamine
Ethanolamine derivative
Prescription or OTC
ExpectorantOver-the-counter
Available as
UnisomMucinex
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
  • Liquid
Used for (click to learn more)
UnisomMucinex
Risk factors for serious side effects
UnisomMucinex
  • Using other drugs with similar ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years or younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Unisom Sleeptabs (Doxylamine) risks & warnings »
    Detailed Mucinex (Guaifenesin) risks & warnings »
    Pregnancy category
    UnisomMucinex
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Shouldn't be used unless you have a full night to sleep.
    • Has fewer side effects than prescription sleep aid medications.
    • Not habit-forming like other sleep aids can be.
    • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
    • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
    • People age 65 years and older have a higher risk of side effects from taking antihistamine medications like Unisom Sleeptabs (Doxylamine). Watch for changes in vision, severe dry mouth, trouble urinating, or constipation. The drowsiness caused by Unisom Sleeptabs (Doxylamine) can make you "unsteady" on your feet, leading to a higher chance of falls.
    No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    UnisomMucinex
    • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
    • Has fewer side effects than prescription sleep aid medications.
    • Available over the counter without a prescription.
    • Not habit-forming like other sleep aids can be.
    • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in liquid and tablet forms.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    Downsides and risks
    UnisomMucinex
    • Shouldn't be used unless you have a full night to sleep.
    • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
    • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
    • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
    • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    Tips from our pharmacists for people taking the medication
    UnisomMucinex
    • Starts working in 30 minutes.
    • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
    • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • If your cough lasts more than 7 days, call your doctor.
    • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    Learn more
    More about UnisomSide effectsReviews & ratingsAlternativesFDA package insert
    More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert