Compare Unisom vs. Mucinex DM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Unisom Sleeptabs
(Doxylamine)

Mucinex Dm
(Dextromethorphan / Guaifenesin)

Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.428076256499134Unisom
Reviews for Unisom Sleeptabs (Doxylamine)
58%
of people say Unisom Sleeptabs (Doxylamine) is worth it
32%
say it works well
11%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
UnisomMucinex DM

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »
How it works
UnisomMucinex DM
Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.
Type of medication
UnisomMucinex DM
Antihistamine
Ethanolamine derivative
Prescription or OTC
Cough suppressantExpectorantOver-the-counter
Available as
UnisomMucinex DM
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
UnisomMucinex DM
Risk factors for serious side effects
UnisomMucinex DM
  • Using other drugs with similar ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years or younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Unisom Sleeptabs (Doxylamine) risks & warnings »
    • Using other medications that affect serotonin
      Detailed Mucinex Dm (Dextromethorphan / Guaifenesin) risks & warnings »
      Pregnancy category
      UnisomMucinex DM
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
      • Don't take it with alcohol or other drugs that make you sleepy.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      • Shouldn't be used unless you have a full night to sleep.
      • Has fewer side effects than prescription sleep aid medications.
      • Not habit-forming like other sleep aids can be.
      • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
      • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
      • People age 65 years and older have a higher risk of side effects from taking antihistamine medications like Unisom Sleeptabs (Doxylamine). Watch for changes in vision, severe dry mouth, trouble urinating, or constipation. The drowsiness caused by Unisom Sleeptabs (Doxylamine) can make you "unsteady" on your feet, leading to a higher chance of falls.
      No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      UnisomMucinex DM
      • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
      • Has fewer side effects than prescription sleep aid medications.
      • Available over the counter without a prescription.
      • Not habit-forming like other sleep aids can be.
      • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
      • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
      • The extended release version of Mucinex DM lasts up to 12 hours.
      Downsides and risks
      UnisomMucinex DM
      • Shouldn't be used unless you have a full night to sleep.
      • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
      • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
      • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
      • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
      • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
      • Can cause sleepiness, dizziness, and an upset stomach.
      Tips from our pharmacists for people taking the medication
      UnisomMucinex DM
      • Starts working in 30 minutes.
      • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
      • Don't take it with alcohol or other drugs that make you sleepy.
      • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
      • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
      • Cough suppressant starts working in 15 to 30 minutes.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
      • If your cough lasts more than 7 days, call your doctor.
      Learn more
      More about UnisomSide effectsReviews & ratingsAlternativesFDA package insert
      More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert