Compare Valium vs. Flexeril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Valium
(diazepam)

Flexeril
(cyclobenzaprine)

Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Relaxes your muscles. Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.15Valium
Reviews for Valium
70%
of people (All ages) say Valium is worth it
53%
say it works well
15%
say it's a big hassle
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Reviews for Flexeril
66%
+4% better vs. Valium
37%
+16% better vs. Valium
14%
-1% worse vs. Valium
1064 reviews
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it
Side effects
ValiumFlexeril

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Sleepiness 100%
  • Headache 17%
  • Dry throat 8%
  • Acne 6%
  • Disturbance in attention 6%
  • Drowsiness 18%
More Flexeril side effects »
How it works
ValiumFlexeril
Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Flexeril (cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.
Type of medication
ValiumFlexeril
Prescription onlyPrescription only
Available as
ValiumFlexeril
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Liquid
Used for
ValiumFlexeril
Risk factors for serious side effects
ValiumFlexeril
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Valium (diazepam) risks & warnings »
  • Taking monoamine oxidase inhibitors (MAOI)
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65 years
  • Recent heart attack
Detailed Flexeril (cyclobenzaprine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ValiumFlexeril
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
No alcohol related info.
Kidneys and liver
ValiumFlexeril
  • Processed by the liver, so might not be the best choice if you have liver problems.
No kidneys and liver related info.
Pain
ValiumFlexeril
No pain related info.
  • Can relieve pain associated with muscle spasms.
Sleep
ValiumFlexeril
  • Can cause temporary dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Taking Flexeril (cyclobenzaprine) may make you feel dizzy or sleepy for the first few days. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
  • Flexeril (cyclobenzaprine) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
Upsides and benefits
ValiumFlexeril
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Effective at relieving muscle spasms caused by a variety of conditions.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
Downsides and risks
ValiumFlexeril
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
Tips from our pharmacists for people taking the medication
ValiumFlexeril
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 30 minutes when swallowed.
  • Helpful with muscle spasms.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Flexeril (cyclobenzaprine) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Flexeril (cyclobenzaprine) is not meant to be used long-term. It should be used for only 2 to 3 weeks maximum.
  • Flexeril (cyclobenzaprine) can cause dry mouth.
  • Take it roughly at the same time every day.
  • If you are using the capsules, you may swallow it whole or sprinkle contents on a tablespoon of applesauce and swallow immediately without chewing.
Learn more
More about ValiumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it