Compare Valium vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Valium (diazepam)

Prescription only

Zanaflex (tizanidine)

Prescription only
Helps you relax.

Valium (diazepam) is effective for occasional or short-term use for anxiety and muscle spasm. Compared to similar drugs, Valium (diazepam) acts very quickly but can have interactions with other medicines.

5.2/ 7 average rating with 976 reviewsforValium
Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

6.0/ 7 average rating with 26 reviewsforZanaflex
  • Valium (diazepam) effectively relieves anxiety and muscle spasms.
  • Valium (diazepam) has less severe withdrawal symptoms compared to other similar drugs.
  • Works very quickly.
  • Available in generic.
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
  • Use of Valium (diazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Valium (diazepam) can be habit-forming, so it's not typically used for long-term treatment.
  • Most people find that their body will get used to Valium (diazepam) levels and they may need higher doses over time to achieve the same effect.
  • People with severe liver problems should not take Valium (diazepam). Several drugs can also interfere with how Valium (diazepam) works.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
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Side effects
The Valium (diazepam) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Dry mouth
  • Sleepiness
  • Weakness
  • Dizziness
  • Urinary tract infection
  • General infection
  • Liver test abnormality
  • Constipation
  • Vomiting
  • Speech disorder
See more detailed side effects
Risks and warnings
  • Decreased breathing from use with opioids

    Taking Valium (diazepam) with opioids, drugs or alcohol

    ...and 1 more risk factors

  • Dependence and withdrawal

    History of substance abuse

    ...and 4 more risk factors

  • Driving impairment

    Alcohol use with Valium (diazepam)

    ...and 1 more risk factors

  • Drug interactions

    Current liver problems

    ...and 1 more risk factors

See more detailed risks and warnings
  • Liver damage

    Taking maximum doses of Zanaflex (tizanidine)

  • Dizziness and low blood pressure

    Age 65 years or older

    ...and 1 more risk factors

  • Sleepiness and driving impairment

    Taking other medications that also cause sleepiness

    ...and 3 more risk factors

  • Withdrawal side effects

    Stopping Zanaflex (tizanidine) suddenly

See more detailed risks and warnings