Compare Vancocin vs. daptomycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vancocin (vancomycin)

Prescription only

Cubicin (daptomycin)

Prescription only
Treats bacterial infections.

Vancocin (vancomycin) is effective in treating C. difficile-associated diarrhea or Staph infection of the small intestine and colon.

Treats bacterial infections.

Cubicin (daptomycin) is an antibiotic that's usually only given in the hospital for serious infections. It can be given at home, but you will have to be taught how to inject it correctly.

Upsides
  • Vancocin (vancomycin) is the first choice medicine to treat C. difficile-associated diarrhea.
  • Available in generic.
  • Available as both a capsule and a liquid.
  • Cubicin (daptomycin) is good at treating severe and complicated bacterial infections.
  • It is able to kill bacteria that have resistance to other antibiotics.
  • Most people who take Cubicin (daptomycin) have few side effects.
  • You usually only need to take it once a day.
Downsides
  • Vancocin (vancomycin) is only given by mouth to treat C. difficile-associated diarrhea or Staph infection of the small intestine and colon. It is not effective for other types of infections.
  • Vancocin (vancomycin) must be taken 3 to 4 times a day.
  • Cubicin (daptomycin) is usually only given for extremely serious infections that haven't responded to other antibiotics.
  • Cubicin (daptomycin) can cause muscle aches and weakness, which can lead to kidney problems.
  • You might need to have more blood tests done while taking Cubicin (daptomycin).
  • Like most antibiotics, it is common to have diarrhea when taking this medicine.
  • While Cubicin (daptomycin) is generic, it is usually very expensive.
Used for
  • Clostridium difficile diarrhea
  • Staphylococcal infection of small intestine and colon
Dosage forms
  • Pill
  • Liquid
  • Injection
Price
Lowest price near you
$250.68
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Reviews
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Side effects
10possible side effects
  • Nausea
    17%
  • Abdominal pain
    15%
  • Low potassium levels
    13%
  • Vomiting
    9%
  • Diarrhea
    9%
  • Fever
    9%
  • Gas
    8%
  • Urinary tract infection
    8%
  • Headache
    7%
  • Swelling
    6%
See more detailed side effects
9possible side effects
  • Diarrhea
    5%
  • Headache
    5%
  • Rash
    4%
  • Abnormal liver tests
    3%
  • Muscle damage
    3%
  • Dizziness
    2%
  • Urinary tract infection
    2%
  • Low blood pressure
    2%
  • Shortness of breath
    2%
See more detailed side effects
Risks and warnings
  • Kidney problems

    Age 65 and older

    ...and 3 more risk factors

  • Hearing loss

    Underlying hearing loss

    ...and 2 more risk factors

See more detailed risks and warnings
  • Allergic reaction

    Allergy to antibiotics

  • Muscle pain & kidney damage

    History of kidney problems

    ...and 1 more risk factors

  • Pneumonia

    Taking Cubicin (daptomycin) for at least 2 to 4 weeks

See more detailed risks and warnings