Compare Vancocin vs. Zyvox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vancocin (vancomycin)

Prescription only

Zyvox (linezolid)

Prescription only
Treats bacterial infections.

Vancocin (vancomycin) is effective in treating C. difficile-associated diarrhea or Staph infection of the small intestine and colon.

Treats bacterial infections.

Zyvox (linezolid) is good first-choice treatment for serious infections caused by gram positive bacteria.

Upsides
  • Vancocin (vancomycin) is the first choice medicine to treat C. difficile-associated diarrhea.
  • Available in generic.
  • Available as both a capsule and a liquid.
  • Zyvox (linezolid) is effective at treating serious infections caused by certain types of bacteria.
  • Zyvox (linezolid) can be taken orally in liquid form or injected if you have trouble swallowing pills.
Downsides
  • Vancocin (vancomycin) is only given by mouth to treat C. difficile-associated diarrhea or Staph infection of the small intestine and colon. It is not effective for other types of infections.
  • Vancocin (vancomycin) must be taken 3 to 4 times a day.
  • Zyvox (linezolid) can cause dangerously high blood pressures when combined with certain depression medications or excessive amounts of cheese or alcohol.
Used for
  • Clostridium difficile diarrhea
  • Staphylococcal infection of small intestine and colon
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Injection
Price
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Reviews
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Side effects
13possible side effects
  • Nausea
    17%
  • Abdominal pain
    15%
  • Low potassium levels
    13%
  • Vomiting
    9%
  • Diarrhea
    9%
  • Fever
    9%
  • Gas
    8%
  • Urinary tract infection
    8%
  • Headache
    7%
  • Swelling
    6%
  • Back pain
    6%
  • Fatigue
    5%
  • Kidney problems
    5%
See more detailed side effects
9possible side effects
  • Diarrhea
    8%
  • Nausea
    7%
  • Headache
    6%
  • Vomiting
    4%
  • Dizziness
    2%
  • Rash
    2%
  • Anemia
    2%
  • Fungal infection of the mouth
    2%
  • Abnormal liver function
    2%
See more detailed side effects
Risks and risk factors
  • Oral use only
  • Kidney problems
    • Age 65 and older
    • Kidney problems
    • Kidney disease
    • Hemodialysis
  • New infection
  • Hearing loss
    • Underlying hearing loss
    • Taking high doses of Vancocin (vancomycin) intravenously
    • Using another medicine that causes hearing loss
See more detailed risks and warnings
  • Blood and bone marrow problems
    • Taking Zyvox (linezolid) for longer than 2 weeks
    • Existing bone marrow disease
    • Use of other medicines that affect the bone marrow suppression
    • Chronic infection
    • Use of other antibiotic therapies
  • Nerve and eye damage
  • Serotonin syndrome
    • Taking drugs for depression, migraines, or pain
  • Infectious diarrhea
    • Taking Zyvox (linezolid) for a long time
  • Acid buildup in the blood (lactic acidosis)
  • Low blood sugar
    • Diabetes
    • Using insulin or other diabetic medications
See more detailed risks and warnings