Compare Vigamox vs. azithromycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vigamox (moxifloxacin)

Prescription only

Zithromax (azithromycin)

Prescription only
Treats eye infections.

Vigamox (moxifloxacin) is effective at treating eye infections, but it can be expensive.

Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

5.5/ 7 average rating with 909 reviewsforazithromycin
  • Infection may start to feel better and clear up on days 5-6.
  • Because it works directly on the eye, you won't get the same side effects (like diarrhea) from taking the pill form.
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
  • May need to use Vigamox (moxifloxacin) multiple times a day, which can be inconvenient.
  • Not available as a generic eye drop medication.
  • Common side effects include eye irritation, eye pain, dry eyes, and teary eyes.
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
Used for
Dosage forms
  • Eye drops
  • Pill
  • Liquid
  • Extended-release liquid
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Side effects
6possible side effects
  • Pinkeye
  • Decreased visual acuity
  • Dry eyes
  • Eye irritation
  • Eye pain
  • Itchy eyes
See more detailed side effects
3possible side effects
  • Vomiting
  • Diarrhea
  • Abdominal pain
See more detailed side effects
Risks and warnings
See more detailed risks and warnings
  • Liver damage

    History of liver disease

  • Myasthenia gravis

    Myasthenia gravis

  • Abnormal heartbeat

    QT prolongation

    ...and 4 more risk factors

See more detailed risks and warnings