Compare Viibryd vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Viibryd (Vilazodone)

Prescription only

Oleptro (Trazodone)

Prescription only
Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

4.0/ 5 average rating with 95 reviewsforViibryd
Improves mood and helps you sleep.

Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.

3.6/ 5 average rating with 59 reviewsforOleptro
Upsides
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
95 reviews so far
67%
saidit'sworth it
63%
saiditworked well
13%
saidit'sa big hassle

Have you used Viibryd (Vilazodone)?

Leave a review
59 reviews so far
73%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle

Have you used Oleptro (Trazodone)?

Leave a review
Side effects
26possible side effects
  • Diarrhea
    28%
  • Nausea
    23%
  • Dizziness
    9%
  • Dry mouth
    8%
  • Insomnia
    6%
  • Vomiting
    5%
  • Decreased libido
    5%
  • Abnormal dreams
    4%
  • Libido decreased
    4%
  • Fatigue
    4%
  • Abnormal orgasm
    4%
  • Dyspepsia
    3%
  • Flatulence
    3%
  • Gastroenteritis
    3%
  • Somnolence
    3%
  • Paresthesia
    3%
  • Restlessness
    3%
  • Orgasm abnormal
    3%
  • Arthralgia
    3%
  • Tremor
    2%
  • Feeling jittery
    2%
  • Palpitations
    2%
  • Delayed ejaculation
    2%
  • Erectile dysfunction
    2%
  • Increased appetite
    2%
  • Sexual dysfunction
    2%
See more detailed side effects
29possible side effects
  • Somnolence/Sedation
    46%
  • Drowsiness
    41%
  • Dry Mouth
    34%
  • Headache
    33%
  • Dizziness/Lightheadedness
    28%
  • Dry mouth
    25%
  • Dizziness
    25%
  • Nausea
    21%
  • Blurred Vision
    15%
  • Fatigue
    15%
  • Nausea/Vomiting
    13%
  • Diarrhea
    9%
  • Constipation
    8%
  • Skin Condition/Edema
    7%
  • Weight Loss
    6%
  • Nasal/Sinus Congestion
    6%
  • Abdominal/Gastric Disorder
    6%
  • Syncope
    5%
  • Musculoskeletal Aches/Pains
    5%
  • Tremors
    5%
  • Nightmares/Vivid Dreams
    5%
  • Weight Gain
    5%
  • Back pain
    5%
  • Vision blurred
    5%
  • Sexual dysfunction
    5%
  • Hypotension
    4%
  • Incoordination
    2%
  • Ejaculation disorders
    2%
  • Decreased libido
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 18 years or younger
  • Monoamine oxidase inhibitor (MAOI) interaction
    • Taking Viibryd (Vilazodone) with MAOIs
    • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Serotonin syndrome
    • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Abnormal bleeding
    • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Risk to fetus
    • Women of childbearing age
  • Eye problems
    • History of glaucoma
  • Activation of mania/hypomania
    • History of bipolar disorder (mixed/mania)
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Seizures
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
  • Painful erection
  • Low blood pressure
    • Age 65 years or older
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings