Compare Vivactil vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vivactil
(protriptyline)

Surmontil
(trimipramine)

Improves your mood. Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Vivactil (protriptyline)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
Side effects
VivactilSurmontil

The Vivactil FDA package insert doesn’t have numbers about how common side effects are.

More about Vivactil side effects »

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »
How it works
VivactilSurmontil
Vivactil (protriptyline) is a tricyclic antidepressant. It regulates mood by raising the amount of serotonin and norepinephrine in the brain.Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.
Type of medication
VivactilSurmontil
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
VivactilSurmontil
  • Pill
  • Pill
Used for
VivactilSurmontil
Risk factors for serious side effects
VivactilSurmontil
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • History of seizures
  • High blood pressure
Detailed Vivactil (protriptyline) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Surmontil (trimipramine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
VivactilSurmontil
No food related info.
  • Can be taken with or without food.
Upsides and benefits
VivactilSurmontil
  • Vivactil (protriptyline) is part of the first choice medicines for treating depression.
  • Compared to similar medicines, Vivactil (protriptyline) is less likely to make you feel sleepy.
  • Available in generic.
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
Downsides and risks
VivactilSurmontil
  • Vivactil (protriptyline) can lower your sex drive more than some other similar medicines.
  • Because Vivactil (protriptyline) can cause dizziness, people age 65 and older need to take precautions when taking Vivactil (protriptyline).
  • Vivactil (protriptyline) can worsen heart conditions. If you have a history of heart problems, you may need to have regular testing for your heart.
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Tips from our pharmacists for people taking the medication
VivactilSurmontil
  • Take Vivactil (protriptyline) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • You might have to take Vivactil (protriptyline) for a few weeks before you notice any changes in your mood.
  • Vivactil (protriptyline) can make you more sensitive to the sun. Wear sunscreen or cover your skin if you're going to be out in the sun for a while.
  • Don't stop taking Vivactil (protriptyline) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since Vivactil (protriptyline) can make you feel dizzy.
  • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
  • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
Learn more
More about VivactilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vivactil (protriptyline)?
Worth itNot sureNot worth it
More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it