Compare Vytorin vs. Antara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(ezetimibe / simvastatin)

Antara
(fenofibrate)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. Antara (Fenofibrate) is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol.
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Coupons for Vytorin
Best available price for 30 (10mg/40mg) tablets of ezetimibe / simvastatin
Coupons for Antara
Best available price for 30 (160mg) tablets of fenofibrate
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Vytorin
Reviews for Vytorin (ezetimibe / simvastatin)
53%
of people (All ages) say Vytorin (ezetimibe / simvastatin) is worth it
36%
say it works well
19%
say it's a big hassle
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
Reviews for Antara (fenofibrate)
27%
-26% worse vs. Vytorin (ezetimibe / simvastatin)
14%
-22% worse vs. Vytorin (ezetimibe / simvastatin)
29%
-10% worse vs. Vytorin (ezetimibe / simvastatin)
Have you used Antara (fenofibrate)?
Worth itNot sureNot worth it
Side effects
VytorinAntara
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
  • Abnormal liver function tests 7%
  • Abdominal pain 1%
  • Increased ast 2%
  • Increased alt 1%
  • Increased creatine phosphokinase 2%
  • Constipation 1%
More Antara side effects »
How it works
VytorinAntara
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Antara (Fenofibrate) is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
VytorinAntara
Prescription only
Prescription only
Available as
VytorinAntara
  • Pill
  • Pill
Used for
VytorinAntara
Risk factors for serious side effects
VytorinAntara
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed Vytorin (ezetimibe / simvastatin) risks & warnings »
  • Taking Antara (Fenofibrate) with statins
  • Past history of liver disease
  • Taking Antara (Fenofibrate) with anticoagulants
Detailed Antara (fenofibrate) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
VytorinAntara
No alcohol related info.
  • Drinking large amounts of alcohol regularly can raise your risk of liver damage.
  • Don't drink a lot of alcohol while taking this medicine.
Kidneys and liver
VytorinAntara
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
  • Reports of liver damage have been reported in people who take Antara (Fenofibrate), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
Upsides and benefits
VytorinAntara
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
VytorinAntara
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
  • In studies, it didn't lower heart disease in people with Type 2 diabetes.
  • According to new guidelines, you shouldn't take this medicine by itself to lower cholesterol.
  • Drinking large amounts of alcohol regularly can raise your risk of liver damage.
  • Different forms and strengths of this medication can't be substituted for each other.
Tips from our pharmacists for people taking the medication
VytorinAntara
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Lowers triglycerides.
  • Can cause backache or headache.
  • Call your doctor if you develop muscle or abdominal pain.
  • Don't drink a lot of alcohol while taking this medicine.
  • Also taking Welchol or Questran? Take this medicine at least 1 hour before or 6 hours after.
  • You should use this medicine in combination with a healthy diet.
Learn more
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
More about AntaraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Antara (fenofibrate)?
Worth itNot sureNot worth it