Compare Vytorin vs. Antara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(Ezetimibe / Simvastatin)

Antara
(Fenofibrate)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. Antara (Fenofibrate) is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.408163265306122Vytorin
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
of people say Vytorin (Ezetimibe / Simvastatin) is worth it
36%
say it works well
19%
say it's a big hassle
Reviews for Antara (Fenofibrate)
27%
25% vs. Vytorin (Ezetimibe / Simvastatin)
14%
22% vs. Vytorin (Ezetimibe / Simvastatin)
29%
10% vs. Vytorin (Ezetimibe / Simvastatin)
Side effects
VytorinAntara
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
  • Abnormal liver function tests 7%
  • Increased ast 2%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Constipation 1%
  • Increased alt 1%
More Antara side effects »
How it works
VytorinAntara
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Antara (Fenofibrate) is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
VytorinAntara
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
VytorinAntara
  • Pill
  • Pill
Used for (click to learn more)
VytorinAntara
Risk factors for serious side effects
VytorinAntara
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
      • Pregnancy
      Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
      • Taking Antara (Fenofibrate) with statins
      • Past history of liver disease
        • Taking Antara (Fenofibrate) with anticoagulants
                Detailed Antara (Fenofibrate) risks & warnings »
                Pregnancy category
                VytorinAntara
                XFDA pregnancy category (Unsafe)

                Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
                • Drinking large amounts of alcohol regularly can raise your risk of liver damage.
                • Don't drink a lot of alcohol while taking this medicine.
                Food
                No specific food-related info.No specific food-related info.
                Kidneys and liver
                • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
                • People on Antara (Fenofibrate) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                VytorinAntara
                • A 2-in-1 cholesterol-lowering combination medicine.
                • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                Downsides and risks
                VytorinAntara
                • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
                • There's no generic available, so it can be expensive.
                • In studies, it didn't lower heart disease in people with Type 2 diabetes.
                • According to new guidelines, you shouldn't take this medicine by itself to lower cholesterol.
                • Drinking large amounts of alcohol regularly can raise your risk of liver damage.
                • Different forms and strengths of this medication can't be substituted for each other.
                Tips from our pharmacists for people taking the medication
                VytorinAntara
                • Take it in the evening.
                • Avoid grapefruit and grapefruit juice while taking this medicine.
                • Can cause headaches or diarrhea.
                • Call your doctor if you develop muscle pain.
                • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                • Lowers triglycerides.
                • Can cause backache or headache.
                • Call your doctor if you develop muscle or abdominal pain.
                • Don't drink a lot of alcohol while taking this medicine.
                • Also taking Welchol or Questran? Take this medicine at least 1 hour before or 6 hours after.
                • You should use this medicine in combination with a healthy diet.
                Learn more
                More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
                More about AntaraSide effectsReviews & ratingsAlternativesFDA package insert