Compare Vytorin vs. Crestor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(Ezetimibe / Simvastatin)

Crestor
(Rosuvastatin)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. Crestor (Rosuvastatin) is one of the most effective statins to improve cholesterol, but the brand name medication is expensive. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Vytorin
Reviews for Vytorin (Ezetimibe / Simvastatin)
53%
of people (All ages) say Vytorin (Ezetimibe / Simvastatin) is worth it
36%
say it works well
19%
say it's a big hassle
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
Reviews for Crestor (Rosuvastatin)
60%
+7% better vs. Vytorin (Ezetimibe / Simvastatin)
47%
+11% better vs. Vytorin (Ezetimibe / Simvastatin)
15%
+4% better vs. Vytorin (Ezetimibe / Simvastatin)
751 reviews
Have you used Crestor (Rosuvastatin)?
Worth itNot sureNot worth it
Side effects
VytorinCrestor
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
  • Headache 1%
  • Nausea 1%
  • Muscle pain 2%
  • Joint pain 1%
  • Diabetes mellitus 1%
  • Dizziness 1%
More Crestor side effects »
How it works
VytorinCrestor
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Crestor (Rosuvastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
VytorinCrestor
Prescription only
Prescription only
Available as
VytorinCrestor
  • Pill
  • Pill
Used for
VytorinCrestor
Risk factors for serious side effects
VytorinCrestor
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
      • Pregnancy
      Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
        • Heavy alcohol use
        • Prior history of chronic liver disease
        • Pregnancy
        Detailed Crestor (Rosuvastatin) risks & warnings »
        Pregnancy

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Alcohol
        VytorinCrestor
        No alcohol related info.
        • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        Kidneys and liver
        VytorinCrestor
        • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
        • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
        • People on Crestor (Rosuvastatin) have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
        • Liver damage has been reported in people who take Crestor (Rosuvastatin). If you notice dark urine or yellowing of the eyes or skin, talk to your doctor. Your doctor may monitor your liver periodically.
        Upsides and benefits
        VytorinCrestor
        • A 2-in-1 cholesterol-lowering combination medicine.
        • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
        • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as hardening of the arteries.
        • In clinical studies, Crestor has the strongest effect on lowering "bad" cholesterol compared to other statins.
        • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
        Downsides and risks
        VytorinCrestor
        • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
        • There's no generic available, so it can be expensive.
        • Even with a generic available in 2016, can be expensive.
        • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
        • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
        • Not safe to use if you're pregnant.
        Tips from our pharmacists for people taking the medication
        VytorinCrestor
        • Take it in the evening.
        • Avoid grapefruit and grapefruit juice while taking this medicine.
        • Can cause headaches or diarrhea.
        • Call your doctor if you develop muscle pain.
        • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
        • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
        • Don't take antacids for at least 2 hours before and after taking this medicine.
        • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
        • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
        Learn more
        More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Vytorin (Ezetimibe / Simvastatin)?
        Worth itNot sureNot worth it
        More about CrestorSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Crestor (Rosuvastatin)?
        Worth itNot sureNot worth it