Compare Vytorin vs. Niaspan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(Ezetimibe / Simvastatin)

Niaspan
(Niacin)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. niacin is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.408163265306122Vytorin
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
of people (All ages) say Vytorin (Ezetimibe / Simvastatin) is worth it
36%
say it works well
19%
say it's a big hassle
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
Reviews for Niaspan (Niacin)
43%
9% vs. Vytorin (Ezetimibe / Simvastatin)
31%
5% vs. Vytorin (Ezetimibe / Simvastatin)
19%
Same vs. Vytorin (Ezetimibe / Simvastatin)
380 reviews
Have you used Niaspan (Niacin)?
Worth itNot sureNot worth it
Side effects
VytorinNiaspan
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
  • Flushing 50%
  • Itching 6%
  • Vomiting 5%
  • Nausea 4%
  • Cough increased 2%
  • Diarrhea 1%
More Niaspan side effects »
How it works
VytorinNiaspan
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.niacin is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver. It may also help your body process cholesterol.
Type of medication
VytorinNiaspan
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Cholesterol-lowering
Nicotinic acid
Prescription only
Available as
VytorinNiaspan
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
VytorinNiaspan
Risk factors for serious side effects
VytorinNiaspan
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
      • Pregnancy
      Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
      • Taking Niaspan (Niacin) with statins
      • Heavy alcohol use
      • Past history of liver disease
      • Diabetes
      • Taking Niaspan (Niacin) with anticoagulants
      Detailed Niaspan (Niacin) risks & warnings »
      Pregnancy

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      VytorinNiaspan
      No alcohol related info.
      • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
      Food
      VytorinNiaspan
      No food related info.
      • You have to take it before bedtime with a low-fat snack.
      • Take it at bedtime with a low-fat snack.
      • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
      Kidneys and liver
      VytorinNiaspan
      • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
      No kidneys and liver related info.
      Pain
      VytorinNiaspan
      No pain related info.
      • Can cause flushing and stomach pain or discomfort.
      Upsides and benefits
      VytorinNiaspan
      • A 2-in-1 cholesterol-lowering combination medicine.
      • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Lowers the risk of a second heart attack.
      • Good for lowering triglycerides (fats).
      • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      Downsides and risks
      VytorinNiaspan
      • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
      • There's no generic available, so it can be expensive.
      • By itself, niacin is not as effective as statins for improving cholesterol.
      • Can cause flushing and stomach pain or discomfort.
      • You have to take it before bedtime with a low-fat snack.
      • If you don't take it regularly, you might have to re-start the medicine at a lower dose.
      Tips from our pharmacists for people taking the medication
      VytorinNiaspan
      • Take it in the evening.
      • Avoid grapefruit and grapefruit juice while taking this medicine.
      • Can cause headaches or diarrhea.
      • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
      • Call your doctor if you develop muscle pain.
      • Take it at bedtime with a low-fat snack.
      • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
      • Can cause flushing.
      • Don't stop taking this medicine suddenly.
      • Call your doctor if you develop muscle pain.
      Learn more
      More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Vytorin (Ezetimibe / Simvastatin)?
      Worth itNot sureNot worth it
      More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Niaspan (Niacin)?
      Worth itNot sureNot worth it