Compare Vytorin vs. Omega 3 Acid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Ezetimibe / Simvastatin)

(Omega-3 Acid)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers triglycerides. Omega-3 Acid is good for lowering triglycerides (fats), but some people can't take it due to allergies.
How it works
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Omega-3 Acid is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it may help the liver remove triglycerides from your body, and also prevent your body from making more triglycerides.
Type of medication
Cholesterol inhibitor
Prescription only
Omega-3 fatty acid
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Vytorin (Ezetimibe / Simvastatin)
of people say Vytorin (Ezetimibe / Simvastatin) is worth it
say it works well
say it's a big hassle
Reviews for Lovaza (Omega-3 Acid)
+7% vs. Vytorin (Ezetimibe / Simvastatin)
+14% vs. Vytorin (Ezetimibe / Simvastatin)
9% vs. Vytorin (Ezetimibe / Simvastatin)
Side effects
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
  • Eructation 3%
  • Indigestion 1%
More Omega 3 Acid side effects »
Risk factors for serious side effects
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
      • Pregnancy
      Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
      • Allergy to fish or shellfish
      • Atrial fibrillation
      Detailed Lovaza (Omega-3 Acid) risks & warnings »
      Pregnancy category
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
      No specific alcohol-related info.
      No specific food-related info.
      • You have to take it with food.
      • Take it with food.
      Kidneys and liver
      • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
      No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • A 2-in-1 cholesterol-lowering combination medicine.
      • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
      • Lowers triglycerides (fats) when combined with exercise and a low cholesterol diet.
      • In studies, Omega-3 Acid has lowered the risk of stroke and heart attack leading to death, especially in people with high cholesterol or high triglycerides.
      Downsides and risks
      • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
      • There's no generic available, so it can be expensive.
      • You can't take it if you're allergic to fish or shellfish.
      • You have to take it with food.
      Tips from our pharmacists for people taking the medication
      • Take it in the evening.
      • Avoid grapefruit and grapefruit juice while taking this medicine.
      • Can cause headaches or diarrhea.
      • Call your doctor if you develop muscle pain.
      • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
      • Lowers triglycerides.
      • Take it with food.
      • Swallow capsules whole.
      • Can cause burping and changes in taste.
      • Don't use if you have an allergy to fish or shellfish.
      • You should use this medicine in combination with a healthy diet.
      Learn more
      More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
      More about Omega 3 AcidSide effectsReviews & ratingsAlternativesFDA package insert