Compare Vytorin vs. Omega 3 Acid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Ezetimibe / Simvastatin)

(Omega-3 Acid)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers triglycerides. Omega-3 Acid is good for lowering triglycerides (fats), but some people can't take it due to allergies.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Vytorin
of people (All ages) say Vytorin is worth it
say it works well
say it's a big hassle
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
Reviews for Omega 3 Acid
-6% worse vs. Vytorin
-14% worse vs. Vytorin
+9% better vs. Vytorin
Have you used Lovaza (Omega-3 Acid)?
Worth itNot sureNot worth it
Side effects
VytorinOmega 3 Acid
  • Influenza 1%
  • Pain in extremity 1%
  • Diarrhea 3%
  • Increased ALT 4%
  • Myalgia 4%
  • Upper respiratory tract infection 4%
  • Any side effect 3%
  • Headache 6%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
  • Dyspepsia 1%
  • Eructation 3%
  • Taste perversion 4%
More Omega 3 Acid side effects »
How it works
VytorinOmega 3 Acid
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Omega-3 Acid is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it may help the liver remove triglycerides from your body, and also prevent your body from making more triglycerides.
Type of medication
VytorinOmega 3 Acid
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
VytorinOmega 3 Acid
  • Pill
  • Pill
Used for
VytorinOmega 3 Acid
Risk factors for serious side effects
VytorinOmega 3 Acid
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
  • Allergy to fish or shellfish
  • Atrial fibrillation
Detailed Lovaza (Omega-3 Acid) risks & warnings »

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

VytorinOmega 3 Acid
No food related info.
  • Take it with food.
  • You have to take it with food.
Kidneys and liver
VytorinOmega 3 Acid
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
No kidneys and liver related info.
Upsides and benefits
VytorinOmega 3 Acid
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Lowers triglycerides (fats) when combined with exercise and a low cholesterol diet.
  • In studies, Omega-3 Acid has lowered the risk of stroke and heart attack leading to death, especially in people with high cholesterol or high triglycerides.
Downsides and risks
VytorinOmega 3 Acid
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
  • You can't take it if you're allergic to fish or shellfish.
  • You have to take it with food.
Tips from our pharmacists for people taking the medication
VytorinOmega 3 Acid
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Lowers triglycerides.
  • Take it with food.
  • Swallow capsules whole.
  • Can cause burping and changes in taste.
  • Don't use if you have an allergy to fish or shellfish.
  • You should use this medicine in combination with a healthy diet.
Learn more
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
More about Omega 3 AcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lovaza (Omega-3 Acid)?
Worth itNot sureNot worth it