Compare Vytorin vs. simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(ezetimibe / simvastatin)

Zocor
(simvastatin)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. Zocor (simvastatin) is a good medication to improve your cholesterol.
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Coupons for Vytorin
Best available price for 30 (10mg/40mg) tablets of vytorin
Coupons for simvastatin
Best available price for 30 (20mg) tablets of simvastatin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Vytorin
Reviews for Vytorin
53%
of people (All ages) say Vytorin is worth it
36%
say it works well
19%
say it's a big hassle
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
Reviews for simvastatin
61%
-8% worse vs. Vytorin
48%
-12% worse vs. Vytorin
14%
-5% worse vs. Vytorin
1176 reviews
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it
Side effects
Vytorinsimvastatin
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
  • Bronchitis 1%
  • Abnormal heart rhythm 1%
  • Scaly, itchy rash 2%
  • Stomach problems 1%
  • Balance problems 1%
  • Headache 1%
More simvastatin side effects »
How it works
Vytorinsimvastatin
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Zocor (simvastatin) is cholesterol-lowering medicine called a statin. It helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).
Type of medication
Vytorinsimvastatin
Prescription onlyPrescription only
Available as
Vytorinsimvastatin
  • Pill
  • Pill
Used for
Vytorinsimvastatin
Risk factors for serious side effects
Vytorinsimvastatin
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed Vytorin (ezetimibe / simvastatin) risks & warnings »
  • Kidney disease
  • High dose of Zocor (simvastatin)
  • Combining Zocor (simvastatin) with other cholesterol-lowering drugs
  • Older age
  • Female gender
Detailed Zocor (simvastatin) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
Vytorinsimvastatin
No interactions related info.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist about the medicines you are taking.
  • Can have more drug interactions than some other drugs in the same class (statins).
Alcohol
Vytorinsimvastatin
No alcohol related info.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
Kidneys and liver
Vytorinsimvastatin
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
  • People on Zocor (simvastatin) have reported muscle pain, which may lead to muscle and kidney damage. This is more likely to happen if you take higher doses of Zocor (simvastatin). If you suddenly feel muscle pain, weakness or fever and you haven't been exercising, stop taking Zocor (simvastatin) and talk to your doctor right away.
  • There are reports of liver damage in people who take Zocor (simvastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function regularly.
Pain
Vytorinsimvastatin
No pain related info.
  • Combining certain medications can increase the risk of muscle pain, muscle damage, and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
Upsides and benefits
Vytorinsimvastatin
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Available in generic.
  • Available in combination pills with other cholesterol medicines.
Downsides and risks
Vytorinsimvastatin
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Can have more drug interactions than some other drugs in the same class (statins).
Tips from our pharmacists for people taking the medication
Vytorinsimvastatin
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist about the medicines you are taking.
Learn more
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
More about simvastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zocor (simvastatin)?
Worth itNot sureNot worth it