Compare Vytorin vs. simvastatin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin (Ezetimibe / Simvastatin)

Prescription only

Zocor (simvastatin)

Prescription only
Lowers cholesterol.

Vytorin is expensive and is no more effective than simvastatin by itself.

4.4/ 7 average rating with 99 reviewsforVytorin
Lowers cholesterol.

Zocor (simvastatin) is a good medication to improve your cholesterol.

5.1/ 7 average rating with 1176 reviewsforsimvastatin
Upsides
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Available in generic.
  • Available in combination pills with other cholesterol medicines.
Downsides
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
  • You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • Can have more drug interactions than some other drugs in the same class (statins).
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$91.93
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$4
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Reviews
99 
53%
think this treatment is worth it
36%
think this treatment works well
19%
think this treatment is a hassle

Have you used Vytorin (Ezetimibe / Simvastatin)?

Leave a review
1176 
61%
think this treatment is worth it
48%
think this treatment works well
14%
think this treatment is a hassle

Have you used Zocor (simvastatin)?

Leave a review
Side effects
8possible side effects
  • Headache
    6%
  • Any side effect
    5%
  • Increased ALT
    4%
  • Myalgia
    4%
  • Upper respiratory tract infection
    4%
  • Diarrhea
    3%
  • Influenza
    2%
  • Pain in extremity
    2%
See more detailed side effects
The Zocor (simvastatin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Muscle pain

    Asian patients taking high-dose niacin

  • Liver damage

    Past history of liver disease

    ...and 1 more risk factors

  • High blood sugar

    Diabetes

  • Harm to fetus

    Pregnancy

See more detailed risks and warnings
  • Muscle pain and kidney damage

    Kidney disease

    ...and 4 more risk factors

  • Liver damage

    Heavy alcohol use

    ...and 1 more risk factors

  • Harm to unborn baby

    Pregnancy

    ...and 1 more risk factors

  • Drug interactions

    Certain drugs can increase the dose of Zocor (simvastatin) in the body

  • High blood sugar

    History of high blood sugar

See more detailed risks and warnings