Compare Vytorin vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(Ezetimibe / Simvastatin)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.408163265306122Vytorin
Reviews for Vytorin (Ezetimibe / Simvastatin)
52%
of people say Vytorin (Ezetimibe / Simvastatin) is worth it
36%
say it works well
19%
say it's a big hassle
Reviews for Trilipix (Fenofibric Acid)
49%
3% vs. Vytorin (Ezetimibe / Simvastatin)
22%
14% vs. Vytorin (Ezetimibe / Simvastatin)
25%
6% vs. Vytorin (Ezetimibe / Simvastatin)
Side effects
VytorinTrilipix
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
How it works
VytorinTrilipix
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
VytorinTrilipix
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
VytorinTrilipix
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
VytorinTrilipix
Risk factors for serious side effects
VytorinTrilipix
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
      • Pregnancy
      Detailed Vytorin (Ezetimibe / Simvastatin) risks & warnings »
      • Taking Trilipix (Fenofibric Acid) with statins
      • Past history of liver disease
        • Taking Trilipix (Fenofibric Acid) with anticoagulants
                  Detailed Trilipix (Fenofibric Acid) risks & warnings »
                  Pregnancy category
                  VytorinTrilipix
                  XFDA pregnancy category (Unsafe)

                  Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
                  No specific alcohol-related info.
                  Food
                  No specific food-related info.No specific food-related info.
                  Kidneys and liver
                  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
                  • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  No specific sleep-related info.No specific sleep-related info.
                  Weight
                  No specific weight-related info.No specific weight-related info.
                  Upsides and benefits
                  VytorinTrilipix
                  • A 2-in-1 cholesterol-lowering combination medicine.
                  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
                  • Good medicine for lowering triglycerides.
                  Downsides and risks
                  VytorinTrilipix
                  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
                  • There's no generic available, so it can be expensive.
                  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
                  • Different forms and strengths of this medication can't be substituted for each other.
                  Tips from our pharmacists for people taking the medication
                  VytorinTrilipix
                  • Take it in the evening.
                  • Avoid grapefruit and grapefruit juice while taking this medicine.
                  • Can cause headaches or diarrhea.
                  • Call your doctor if you develop muscle pain.
                  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                  • Can be used with other medications to help lower cholesterol.
                  • Lowers triglycerides.
                  • Can raise your chance of getting colds and flu.
                  • Call your doctor if you develop muscle or abdominal pain.
                  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
                  Learn more
                  More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
                  More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert