Compare Vytorin vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vytorin
(ezetimibe / simvastatin)

Trilipix
(fenofibric acid)

Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Vytorin
Reviews for Vytorin
53%
of people (All ages) say Vytorin is worth it
36%
say it works well
19%
say it's a big hassle
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
Reviews for Trilipix
50%
+3% better vs. Vytorin
22%
+14% better vs. Vytorin
25%
+6% better vs. Vytorin
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
Side effects
VytorinTrilipix
  • Headache 1%
  • Any side effect 3%
  • Myalgia 4%
  • Upper respiratory tract infection 4%
  • Increased ALT 4%
  • Diarrhea 3%
  • Influenza 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
  • Headache 13%
  • Back Pain 6%
  • Pain in Extremity 5%
  • Upper respiratory tract infection 5%
  • Nausea 4%
  • Nasopharyngitis 4%
  • Diarrhea 4%
  • Arthralgia 4%
  • Pain 4%
  • Dizziness 4%
More Trilipix side effects »
How it works
VytorinTrilipix
Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
VytorinTrilipix
Prescription onlyPrescription only
Available as
VytorinTrilipix
  • Pill
  • Pill
  • Extended release
Used for
VytorinTrilipix
Risk factors for serious side effects
VytorinTrilipix
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed Vytorin (ezetimibe / simvastatin) risks & warnings »
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed Trilipix (fenofibric acid) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
VytorinTrilipix
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
Upsides and benefits
VytorinTrilipix
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
Downsides and risks
VytorinTrilipix
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
Tips from our pharmacists for people taking the medication
VytorinTrilipix
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it