Compare Vyvanse vs. Adderall

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vyvanse
(Lisdexamfetamine)

Adderall
(Dextroamphetamine / Amphetamine)

Helps you focus and stay alert. Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.Helps you focus and stay alert. Adderall (Dextroamphetamine / Amphetamine) is a first-choice treatment for ADHD that's available as a generic, but it's a stimulant, so it can cause insomnia and other side effects.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.03Vyvanse
Reviews for Vyvanse (Lisdexamfetamine)
67%
of people (All ages) say Vyvanse (Lisdexamfetamine) is worth it
49%
say it works well
17%
say it's a big hassle
491 reviews
Have you used Vyvanse (Lisdexamfetamine)?
Worth itNot sureNot worth it
Reviews for Adderall (Dextroamphetamine / Amphetamine)
74%
+7% better vs. Vyvanse (Lisdexamfetamine)
53%
+4% better vs. Vyvanse (Lisdexamfetamine)
16%
+1% better vs. Vyvanse (Lisdexamfetamine)
1309 reviews
Have you used Adderall (Dextroamphetamine / Amphetamine)?
Worth itNot sureNot worth it
Side effects
VyvanseAdderall
  • Decreased appetite 35%
  • Sleep difficulty 20%
  • Abdominal pain upper 6%
  • Irritability 10%
  • Any side effect 8%
  • Vomiting 5%
  • Weight loss 8%
  • Nausea 3%
  • Dry mouth 5%
  • Dizziness 5%
More Vyvanse side effects »

The Adderall FDA package insert doesn’t have numbers about how common side effects are.

More about Adderall side effects »
How it works
VyvanseAdderall
Vyvanse (Lisdexamfetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.Adderall (Dextroamphetamine / Amphetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.
Type of medication
VyvanseAdderall
Prescription only
Prescription only
Available as
VyvanseAdderall
  • Pill
  • Pill
  • Extended release
Used for
VyvanseAdderall
Risk factors for serious side effects
VyvanseAdderall
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • History of drug abuse
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Children ages 6 to 12
    Detailed Vyvanse (Lisdexamfetamine) risks & warnings »
    • History of heart problems
    • History of drug abuse
    • Taking more than the prescribed dose
    • History of high blood pressure
    • History of psychotic episodes
    • History of Bipolar Disorder
    • Taking with alcohol or drugs
    • Children ages 7 to 10
    Detailed Adderall (Dextroamphetamine / Amphetamine) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    VyvanseAdderall
    • Don't take it with alcohol or drugs.
    • Don't take it with alcohol or drugs.
    Weight
    VyvanseAdderall
    No weight related info.
    • Can cause blurry vision, loss of appetite, weight loss, headache, dry mouth, or anxious feelings.
    Upsides and benefits
    VyvanseAdderall
    • First-choice medication to treat ADHD.
    • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
    • Usually dosed once a day, so parents don't need to send the medication with their children to school.
    • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
    • First-choice medication to treat ADHD.
    • Adderall (Dextroamphetamine / Amphetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
    • Available as a generic medication.
    • Available in both immediate and extended release forms.
    • The capsules can be opened, mixed in a spoonful of applesauce, and swallowed if you can't swallow the whole capsules.
    Downsides and risks
    VyvanseAdderall
    • Has to be taken in the morning, otherwise it can cause insomnia later that night.
    • Not available as a generic medication, so it can be expensive.
    • It's a controlled medication and should be locked up to prevent potential abuse.
    • Not safe for people with a history of heart problems.
    • Has to be taken in the morning and early afternoon, otherwise it can cause insomnia.
    • It's a controlled medication and should be locked up to prevent potential abuse.
    • Not safe for people with a history of heart problems.
    • For schooled-aged children, the second dose will likely need to be given at school.
    Tips from our pharmacists for people taking the medication
    VyvanseAdderall
    • Take Vyvanse (Lisdexamfetamine) early in the morning to prevent insomnia later that night.
    • Avoid driving the first few days that you take Vyvanse (Lisdexamfetamine) until you know how your body reacts to it.
    • Don't take it with alcohol or drugs.
    • Store it in a locked area to prevent abuse.
    • It can cause changes in your mood.
    • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
    • Can cause blurry vision, loss of appetite, weight loss, headache, dry mouth, or anxious feelings.
    • Don't take it with alcohol or drugs.
    • Can cause trouble sleeping, so don't take it too close to bedtime.
    • If using the extended-release version, the first dose is best taken right after waking up in the morning.
    • Capsules can be opened and sprinkled on applesauce, which can then be swallowed without chewing.
    Learn more
    More about VyvanseSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Vyvanse (Lisdexamfetamine)?
    Worth itNot sureNot worth it
    More about AdderallSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Adderall (Dextroamphetamine / Amphetamine)?
    Worth itNot sureNot worth it