Compare Vyvanse vs. Dexedrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vyvanse (Lisdexamfetamine)

Prescription only
Helps you focus and stay alert.

Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.

5.0/ 7 average rating with 491 reviewsforVyvanse
Treats attention deficit disorder.

Dexedrine (dextroamphetamine) is an effective medicine for treatment of ADHD, but often abused for recreational purposes.

5.9/ 7 average rating with 28 reviewsforDexedrine
Upsides
  • First-choice medication to treat ADHD.
  • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • Usually dosed once a day, so parents don't need to send the medication with their children to school.
  • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
  • Recommended as a first-choice treatment of ADHD.
  • Available as generic version.
  • For more flexible dosing schedule, Dexedrine (dextroamphetamine) is available in short and long formulations.
  • If you have difficulty swallowing pills, Dexedrine (dextroamphetamine) is available as a liquid.
Downsides
  • Has to be taken in the morning, otherwise it can cause insomnia later that night.
  • Not available as a generic medication, so it can be expensive.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
  • Taking Dexedrine (dextroamphetamine) can decrease your appetite.
  • If taken late in the day, Dexedrine (dextroamphetamine) can cause insomnia.
  • People who take high doses of Dexedrine (dextroamphetamine) are more likely to have anxiety, restlessness, or irritability.
  • Requires a new prescription from your doctor every month.
  • Not a good option if you have a history of seizures.
  • Can be habit-forming so make sure you use it only as prescribed.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Liquid
Price
Lowest price near you
$285.21
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$54.11
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Reviews
491 
67%
think this treatment is worth it
49%
think this treatment works well
17%
think this treatment is a hassle

Have you used Vyvanse (Lisdexamfetamine)?

Leave a review
28 
89%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

Have you used Dexedrine (dextroamphetamine)?

Leave a review
Side effects
10possible side effects
  • Decreased Appetite
    27%
  • Insomnia
    27%
  • Dry Mouth
    26%
  • Diarrhea
    7%
  • Nausea
    7%
  • Any side effect
    6%
  • Anxiety
    6%
  • Anorexia
    5%
  • Feeling Jittery
    4%
  • Agitation
    3%
See more detailed side effects
The Dexedrine (dextroamphetamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • High blood pressure

    Taking monoamine oxidase inhibitors (MAOI) 14 days before starting

  • Abuse and dependence

    History of drug abuse

  • Serious or life-threatening cardiovascular events

    History of heart problems

  • Aggressive behavior and psychosis

    History of psychotic episodes

    ...and 1 more risk factors

  • Long-term growth suppression

    Children ages 6 to 12

See more detailed risks and warnings
  • Abuse and dependence

    History of drug abuse

  • Serious or life-threatening heart problems

    History of heart problems

  • Aggressive behavior and psychosis

    History of psychotic episodes

    ...and 1 more risk factors

  • Long-term growth suppression

    Children

  • Seizures

    History of seizures

  • Serotonin Syndrome (rare, life-threatening)

    Using other medicines that increase serotonin levels in the brain

See more detailed risks and warnings