Compare Vyvanse vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vyvanse
(Lisdexamfetamine)

Provigil
(Modafinil)

Helps you focus and stay alert. Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.924276169265033Vyvanse
Reviews for Vyvanse (Lisdexamfetamine)
65%
of people say Vyvanse (Lisdexamfetamine) is worth it
46%
say it works well
18%
say it's a big hassle
Reviews for Provigil (Modafinil)
78%
+13% vs. Vyvanse (Lisdexamfetamine)
70%
+24% vs. Vyvanse (Lisdexamfetamine)
4%
+14% vs. Vyvanse (Lisdexamfetamine)
Side effects
VyvanseProvigil
  • Decreased appetite 35%
  • Dry mouth 23%
  • Sleep difficulty 19%
  • Any side effect 8%
  • Abdominal pain upper 6%
  • Vomiting 5%
  • Drowsiness 1%
  • Fever 1%
More Vyvanse side effects »
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »
How it works
VyvanseProvigil
Vyvanse (Lisdexamfetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.
Type of medication
VyvanseProvigil
StimulantPrescription only
StimulantPrescription only
Available as
VyvanseProvigil
  • Pill
  • Pill
Used for (click to learn more)
VyvanseProvigil
Risk factors for serious side effects
VyvanseProvigil
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • History of drug abuse
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Children ages 6 to 12
    Detailed Vyvanse (Lisdexamfetamine) risks & warnings »
    • Taking with alcohol
    • Taking other medicines that make you less alert
        • Current kidney problems
        • Current liver problems
        • History of heart problems
        • History of psychiatric disorder
        • History of bipolar disorder
        Detailed Provigil (Modafinil) risks & warnings »
        Pregnancy category
        VyvanseProvigil
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • Don't take it with alcohol or drugs.
        • Don't drink alcohol with Provigil (Modafinil).
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • Not a good choice if you have liver or kidney problems.
        • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.
        • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
        • Doesn't negatively affect daytime sleep.
        Weight
        • Appetite suppression may occur. In clinical studies, long-term treatment with stimulants similar to Vyvanse (Lisdexamfetamine) caused a temporary slowing of growth rate (both height and weight) in children ages six to twelve years. Doctors should monitor children's growth during treatment.
        No specific weight-related info.
        Upsides and benefits
        VyvanseProvigil
        • First-choice medication to treat ADHD.
        • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
        • Usually dosed once a day, so parents don't need to send the medication with their children to school.
        • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
        • It's a non-amphetamine medicine that helps improve alertness.
        • Available in a generic version.
        • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
        • Doesn't negatively affect daytime sleep.
        Downsides and risks
        VyvanseProvigil
        • Has to be taken in the morning, otherwise it can cause insomnia later that night.
        • Not available as a generic medication, so it can be expensive.
        • It's a controlled medication and should be locked up to prevent potential abuse.
        • Not safe for people with a history of heart problems.
        • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
        • Interacts with many other medications.
        • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
        • Not a good choice if you have liver or kidney problems.
        Tips from our pharmacists for people taking the medication
        VyvanseProvigil
        • Take Vyvanse (Lisdexamfetamine) early in the morning to prevent insomnia later that night.
        • Avoid driving the first few days that you take Vyvanse (Lisdexamfetamine) until you know how your body reacts to it.
        • Don't take it with alcohol or drugs.
        • Store it in a locked area to prevent abuse.
        • It can cause changes in your mood.
        • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
        • Take Provigil (Modafinil) about an hour before you need to be fully alert.
        • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
        • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
        • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
        • Tell your doctor right away if you break out in a rash.
        • Don't drink alcohol with Provigil (Modafinil).
        Learn more
        More about VyvanseSide effectsReviews & ratingsAlternativesFDA package insert
        More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert