Compare Vyvanse vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vyvanse (Lisdexamfetamine)

Prescription only

Provigil (Modafinil)

Prescription only
Helps you focus and stay alert.

Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.

5.0/ 7 average rating with 491 reviewsforVyvanse
Improves alertness.

Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.

5.8/ 7 average rating with 28 reviewsforProvigil
Upsides
  • First-choice medication to treat ADHD.
  • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • Usually dosed once a day, so parents don't need to send the medication with their children to school.
  • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
Downsides
  • Has to be taken in the morning, otherwise it can cause insomnia later that night.
  • Not available as a generic medication, so it can be expensive.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$285.21
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Lowest price near you
$35
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Reviews
491 
67%
think this treatment is worth it
49%
think this treatment works well
17%
think this treatment is a hassle

Have you used Vyvanse (Lisdexamfetamine)?

Leave a review
28 
82%
think this treatment is worth it
71%
think this treatment works well
4%
think this treatment is a hassle

Have you used Provigil (Modafinil)?

Leave a review
Side effects
10possible side effects
  • Decreased Appetite
    27%
  • Insomnia
    27%
  • Dry Mouth
    26%
  • Diarrhea
    7%
  • Nausea
    7%
  • Any side effect
    6%
  • Anxiety
    6%
  • Anorexia
    5%
  • Feeling Jittery
    4%
  • Agitation
    3%
See more detailed side effects
10possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Any side effect
    8%
  • Nervousness
    7%
  • Rhinitis
    7%
  • Back Pain
    6%
  • Diarrhea
    6%
  • Dyspepsia
    5%
  • Insomnia
    5%
  • Anxiety
    5%
See more detailed side effects
Risks and warnings
  • High blood pressure

    Taking monoamine oxidase inhibitors (MAOI) 14 days before starting

  • Abuse and dependence

    History of drug abuse

  • Serious or life-threatening cardiovascular events

    History of heart problems

  • Aggressive behavior and psychosis

    History of psychotic episodes

    ...and 1 more risk factors

  • Long-term growth suppression

    Children ages 6 to 12

See more detailed risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Increased side effects

    Current kidney problems

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

  • Suicidal thoughts or behavior | Mania

    History of psychiatric disorder

    ...and 1 more risk factors

See more detailed risks and warnings