Compare Vyvanse vs. Strattera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vyvanse
(Lisdexamfetamine)

Strattera
(Atomoxetine)

Helps you focus and stay alert. Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.Helps you focus and stay alert. Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.
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Reviews & ratings
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4.924276169265033Vyvanse
Reviews for Vyvanse (Lisdexamfetamine)
65%
of people say Vyvanse (Lisdexamfetamine) is worth it
46%
say it works well
18%
say it's a big hassle
Reviews for Strattera (Atomoxetine)
45%
20% vs. Vyvanse (Lisdexamfetamine)
32%
14% vs. Vyvanse (Lisdexamfetamine)
25%
7% vs. Vyvanse (Lisdexamfetamine)
Side effects
VyvanseStrattera
  • Decreased appetite 35%
  • Dry mouth 23%
  • Sleep difficulty 19%
  • Any side effect 8%
  • Abdominal pain upper 6%
  • Vomiting 5%
  • Drowsiness 1%
  • Fever 1%
More Vyvanse side effects »
  • Nausea 20%
  • Dry mouth 15%
  • Decreased appetite 13%
  • Abdominal pain 8%
  • Drowsiness 7%
  • Impotence 7%
  • Sleep difficulty 7%
  • Dizziness 5%
  • Constipation 5%
  • Difficulty with urination flow 5%
More Strattera side effects »
How it works
VyvanseStrattera
Vyvanse (Lisdexamfetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.Strattera (Atomoxetine) is a norepinephrine reuptake inhibitor (non-stimulant). Researchers don't know exactly how it works for ADHD, but it increases norepinephrine activity in the brain, which affects attention and behavior.
Type of medication
VyvanseStrattera
StimulantPrescription only
Selective norepinephrine reuptake inhibitor (SNRI)Prescription only
Available as
VyvanseStrattera
  • Pill
  • Pill
Used for (click to learn more)
VyvanseStrattera
Risk factors for serious side effects
VyvanseStrattera
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • History of drug abuse
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Children ages 6 to 12
    Detailed Vyvanse (Lisdexamfetamine) risks & warnings »
    • Age below 18
      • History of heart problems
      • History of psychotic episodes
      • History of Bipolar Disorder
          • Starting Strattera (Atomoxetine) before puberty
          Detailed Strattera (Atomoxetine) risks & warnings »
          Pregnancy category
          VyvanseStrattera
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          • Don't take it with alcohol or drugs.
          No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.
          • It can cause changes in sex drive.
          • There have been reports of men having an erection lasting more than 4 hours while on Strattera (Atomoxetine). This has been rare. If not treated in time, this can cause permanent damage to your penis, including impotence. Talk to your doctor immediately or go to the emergency room if this happens.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Appetite suppression may occur. In clinical studies, long-term treatment with stimulants similar to Vyvanse (Lisdexamfetamine) caused a temporary slowing of growth rate (both height and weight) in children ages six to twelve years. Doctors should monitor children's growth during treatment.
          • Appetite suppression may occur. In clinical studies, long-term treatment with stimulants similar to Strattera (Atomoxetine) caused a temporary slowing of growth rate (both height and weight) in children who started the medication before they started puberty. Doctors should monitor children's growth during treatment.
          Upsides and benefits
          VyvanseStrattera
          • First-choice medication to treat ADHD.
          • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
          • Usually dosed once a day, so parents don't need to send the medication with their children to school.
          • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
          • One of the few medications used to treat ADHD that's not a stimulant.
          • It isn't a controlled substance.
          • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
          • You usually only need to take it once a day.
          Downsides and risks
          VyvanseStrattera
          • Has to be taken in the morning, otherwise it can cause insomnia later that night.
          • Not available as a generic medication, so it can be expensive.
          • It's a controlled medication and should be locked up to prevent potential abuse.
          • Not safe for people with a history of heart problems.
          • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
          • It's only available as a brand name medication, so it can be expensive.
          Tips from our pharmacists for people taking the medication
          VyvanseStrattera
          • Take Vyvanse (Lisdexamfetamine) early in the morning to prevent insomnia later that night.
          • Avoid driving the first few days that you take Vyvanse (Lisdexamfetamine) until you know how your body reacts to it.
          • Don't take it with alcohol or drugs.
          • Store it in a locked area to prevent abuse.
          • It can cause changes in your mood.
          • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
          • It can cause changes in sex drive.
          • It can also cause changes in your mood.
          • Take it at the same time every day.
          • Common side effects include decreased appetite, nausea, and constipation.
          • The capsules can't be opened and need to be swallowed whole.
          • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
          Learn more
          More about VyvanseSide effectsReviews & ratingsAlternativesFDA package insert
          More about StratteraSide effectsReviews & ratingsAlternativesFDA package insert