Compare Vyvanse vs. Strattera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vyvanse
(lisdexamfetamine)

Strattera
(atomoxetine)

Helps you focus and stay alert. Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.Helps you focus and stay alert. Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.
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Coupons for Vyvanse
Best available price for 30 (30mg) capsules of lisdexamfetamine
Coupons for Strattera
Best available price for 30 (40mg) tablets of atomoxetine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.03Vyvanse
Reviews for Vyvanse (lisdexamfetamine)
67%
of people (All ages) say Vyvanse (lisdexamfetamine) is worth it
49%
say it works well
17%
say it's a big hassle
491 reviews
Have you used Vyvanse (lisdexamfetamine)?
Worth itNot sureNot worth it
Reviews for Strattera (atomoxetine)
46%
-21% worse vs. Vyvanse (lisdexamfetamine)
32%
-17% worse vs. Vyvanse (lisdexamfetamine)
24%
-7% worse vs. Vyvanse (lisdexamfetamine)
Have you used Strattera (atomoxetine)?
Worth itNot sureNot worth it
Side effects
VyvanseStrattera
  • Decreased appetite 35%
  • Sleep difficulty 20%
  • Abdominal pain upper 6%
  • Irritability 10%
  • Any side effect 8%
  • Vomiting 5%
  • Weight loss 8%
  • Nausea 3%
  • Dry mouth 5%
  • Dizziness 5%
More Vyvanse side effects »
  • Headache 4%
  • Abdominal pain 8%
  • Decreased appetite 12%
  • Vomiting 5%
  • Drowsiness 7%
  • Changes in heart rate or blood pressure 10%
  • Nausea 5%
  • Fatigue 5%
  • Irritability 3%
  • Dizziness 3%
More Strattera side effects »
How it works
VyvanseStrattera
Vyvanse (Lisdexamfetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.Strattera (Atomoxetine) is a norepinephrine reuptake inhibitor (non-stimulant). Researchers don't know exactly how it works for ADHD, but it increases norepinephrine activity in the brain, which affects attention and behavior.
Type of medication
VyvanseStrattera
Prescription only
Prescription only
Available as
VyvanseStrattera
  • Pill
  • Pill
Used for
VyvanseStrattera
Risk factors for serious side effects
VyvanseStrattera
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • History of drug abuse
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
Detailed Vyvanse (lisdexamfetamine) risks & warnings »
  • Age below 18
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Starting Strattera (Atomoxetine) before puberty
Detailed Strattera (atomoxetine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
VyvanseStrattera
  • Don't take it with alcohol or drugs.
No alcohol related info.
Upsides and benefits
VyvanseStrattera
  • First-choice medication to treat ADHD.
  • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • Usually dosed once a day, so parents don't need to send the medication with their children to school.
  • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
  • One of the few medications used to treat ADHD that's not a stimulant.
  • It isn't a controlled substance.
  • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • You usually only need to take it once a day.
Downsides and risks
VyvanseStrattera
  • Has to be taken in the morning, otherwise it can cause insomnia later that night.
  • Not available as a generic medication, so it can be expensive.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
  • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
  • It's only available as a brand name medication, so it can be expensive.
Tips from our pharmacists for people taking the medication
VyvanseStrattera
  • Take Vyvanse (Lisdexamfetamine) early in the morning to prevent insomnia later that night.
  • Avoid driving the first few days that you take Vyvanse (Lisdexamfetamine) until you know how your body reacts to it.
  • Don't take it with alcohol or drugs.
  • Store it in a locked area to prevent abuse.
  • It can cause changes in your mood.
  • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
  • It can cause changes in sex drive.
  • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
  • It can also cause changes in your mood.
  • Take it at the same time every day.
  • Common side effects include decreased appetite, nausea, and constipation.
  • The capsules can't be opened and need to be swallowed whole.
Learn more
More about VyvanseSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vyvanse (lisdexamfetamine)?
Worth itNot sureNot worth it
More about StratteraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Strattera (atomoxetine)?
Worth itNot sureNot worth it