Compare Wellbutrin vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Wellbutrin
(Bupropion)

Oleptro
(Trazodone)

Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.610027855153203Wellbutrin
Reviews for Wellbutrin (Bupropion)
58%
of people say Wellbutrin (Bupropion) is worth it
38%
say it works well
13%
say it's a big hassle
Reviews for Oleptro (Trazodone)
72%
+14% vs. Wellbutrin (Bupropion)
48%
+10% vs. Wellbutrin (Bupropion)
24%
11% vs. Wellbutrin (Bupropion)
Side effects
WellbutrinOleptro
  • Tremor 13%
  • Dry mouth 10%
  • Agitation 10%
  • Constipation 9%
  • Excessive sweating 7%
  • Dizziness 6%
  • Blurred vision 5%
  • Nausea/vomiting 4%
  • Headache/migraine 4%
  • Menstrual complaints 4%
More Wellbutrin side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
WellbutrinOleptro
Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
WellbutrinOleptro
Antidepressant
Norepinephrine-dopamine reuptake inhibitor
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
WellbutrinOleptro
  • Pill
  • Extended release
  • Pill
  • Extended release
Used for (click to learn more)
WellbutrinOleptro
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Wellbutrin (Bupropion), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)
Risk factors for serious side effects
WellbutrinOleptro
  • Age 24 years or younger
  • History of depression
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Withdrawing from nicotine
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Current kidney problems
  • Current liver problems
    Detailed Wellbutrin (Bupropion) risks & warnings »
    • Age 24 years or younger
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
      • Age 65 years or older
      • Alcohol
      • Taking other medicines that make you less alert
      Detailed Oleptro (Trazodone) risks & warnings »
      Pregnancy category
      WellbutrinOleptro
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
      No specific kidneys and liver-related info.
      Sex
      • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
      • Can be taken with other antidepressants to counteract their sexual side effects.
      • There are no sexual side effects from this medication.
      • Fewer sexual side effects than many other antidepressants.
      • Seek medical attention for unwanted, persistent erection.
      • Rarely, Oleptro (Trazodone) can cause a painful, persistent erection for 4 hours or more. Seek medical attention.
      Sleep
      • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      Weight
      • It's less likely to cause weight gain than other antidepressants.
      • Wellbutrin (Bupropion) may cause weight loss. Talk to your doctor if weight loss is not desirable.
      No specific weight-related info.
      Upsides and benefits
      WellbutrinOleptro
      • Effective at relieving depression symptoms.
      • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
      • Can be taken with other antidepressants to counteract their sexual side effects.
      • Has some stimulant effects, so it can be energizing.
      • Can help with ADHD symptoms.
      • Also used to suppress appetite and help you quit smoking.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Fewer sexual side effects than many other antidepressants.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      WellbutrinOleptro
      • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
      • Generally not as good as other antidepressants for people who have anxiety.
      • It's less likely to cause weight gain than other antidepressants.
      • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
      • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      WellbutrinOleptro
      • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • There are no sexual side effects from this medication.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Makes you sleepy. Take at bedtime.
      • Can cause temporary dry mouth and upset stomach.
      • Seek medical attention for unwanted, persistent erection.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about WellbutrinSide effectsReviews & ratingsAlternativesFDA package insert
      More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert