Compare Wellbutrin vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Wellbutrin
(Bupropion)

Remeron
(Mirtazapine)

Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.66Wellbutrin
Reviews for Wellbutrin (Bupropion)
60%
of people (All ages) say Wellbutrin (Bupropion) is worth it
40%
say it works well
13%
say it's a big hassle
1164 reviews
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it
Reviews for Remeron (Mirtazapine)
45%
15% vs. Wellbutrin (Bupropion)
39%
1% vs. Wellbutrin (Bupropion)
26%
13% vs. Wellbutrin (Bupropion)
152 reviews
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it
Side effects
WellbutrinRemeron
  • Tremor 13%
  • Dry mouth 10%
  • Agitation 10%
  • Constipation 9%
  • Excessive sweating 7%
  • Dizziness 6%
  • Blurred vision 5%
  • Nausea/vomiting 4%
  • Headache/migraine 4%
  • Menstrual complaints 4%
More Wellbutrin side effects »

The Remeron FDA package insert doesn’t have numbers about how common side effects are.

More about Remeron side effects »
How it works
WellbutrinRemeron
Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
WellbutrinRemeron
Antidepressant
Norepinephrine-dopamine reuptake inhibitor
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
WellbutrinRemeron
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for (click to learn more)
WellbutrinRemeron
Risk factors for serious side effects
WellbutrinRemeron
  • Age 24 years or younger
  • History of depression
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Withdrawing from nicotine
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
WellbutrinRemeron
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
No alcohol related info.
Kidneys and liver
WellbutrinRemeron
  • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
No kidneys and liver related info.
Weight
WellbutrinRemeron
  • It's less likely to cause weight gain than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Can increase appetite and weight.
  • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
Upsides and benefits
WellbutrinRemeron
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
  • Good option for people who are underweight or frail, because it can help you gain weight.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
WellbutrinRemeron
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
WellbutrinRemeron
  • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • There are no sexual side effects from this medication.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Makes you sleepy. Take at bedtime.
  • Can increase appetite and weight.
  • Takes 8 to 12 weeks to see full effects on mood.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about WellbutrinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it
More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it