Compare Wellbutrin vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Wellbutrin (Bupropion)

Prescription only

Remeron (mirtazapine)

Prescription only
Improves mood.

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

4.7/ 7 average rating with 1164 reviewsforWellbutrin
Improves mood.

Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.

4.5/ 7 average rating with 152 reviewsforRemeron
Upsides
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Price
Lowest price near you
$19.91
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$10
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Reviews
1164 
60%
think this treatment is worth it
40%
think this treatment works well
13%
think this treatment is a hassle

Have you used Wellbutrin (Bupropion)?

Leave a review
152 
45%
think this treatment is worth it
39%
think this treatment works well
26%
think this treatment is a hassle

Have you used Remeron (mirtazapine)?

Leave a review
Side effects
10possible side effects
  • Agitation
    32%
  • Dry mouth
    28%
  • Constipation
    26%
  • Headache/migraine
    26%
  • Nausea/vomiting
    23%
  • Dizziness
    22%
  • Excessive sweating
    22%
  • Tremor
    21%
  • Sleepiness
    20%
  • Insomnia
    19%
See more detailed side effects
The Remeron (mirtazapine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Psychiatric effects for smoking cessation

    History of depression

    ...and 3 more risk factors

  • Seizures

    History of seizures

    ...and 4 more risk factors

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

  • Increased side effects

    Current kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Driving impairment

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings