Compare Xanax vs. chlordiazepoxide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Xanax (alprazolam)

Prescription only
Helps you relax.

Xanax (alprazolam) effectively treats occasional or short-term anxiety and panic attacks. Compared to similar drugs, it is more likely to cause withdrawal symptoms and can have more interactions with some medicines.

5.3/ 7 average rating with 1287 reviewsforXanax
Reduces anxiety.

Librium (chlordiazepoxide) is good for lowering anxiety since its effects aren't as strong as similar medicines; however, it lasts longer in the body and can be more dangerous in older people.

  • Xanax (alprazolam) can be used to manage anxiety associated with depression.
  • Works very quickly - in hours.
  • Available in generic.
  • Librium (chlordiazepoxide) is available as a generic.
  • Because Librium (chlordiazepoxide) lasts longer in the body, it's preferred for alcohol withdrawal since it's less likely to cause seizures.
  • Librium (chlordiazepoxide) can be used by itself, or with antidepressants to help lower anxiety.
  • Use of Xanax (alprazolam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Xanax (alprazolam) can be habit-forming, so it's not typically used for long-term treatment.
  • Compared to other similar drugs, Xanax (alprazolam) is more likely to cause withdrawal symptoms if you take it for a long time and then stop suddenly.
  • If you have liver problems, Xanax (alprazolam) may not be the best choice since it is processed by the liver. Several drugs can also interfere with how Xanax (alprazolam) works. Talk to your doctor to see if Xanax (alprazolam) is right for you.
  • Librium (chlordiazepoxide) lasts much longer in older people, so it's not safe to use if you're age 65 or older.
  • Librium (chlordiazepoxide) is not as strong as similar medicines, so it's only really useful to calm anxiety and for alcohol withdrawal.
  • Librium (chlordiazepoxide) can be addictive, so you should use it for as short of a time as possible.
Used for
Dosage forms
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
  • Pill
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Side effects
10possible side effects
  • Drowsiness
  • Lightheadedness
  • Dry mouth
  • Depression
  • Headache
  • Confusion
  • Constipation
  • Diarrhea
  • Nausea/vomiting
  • Difficulty sleeping
See more detailed side effects
The Librium (chlordiazepoxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Decreased breathing from use with opioids

    Taking Xanax (alprazolam) with opioids, drugs or alcohol

    ...and 1 more risk factors

  • Dependence and withdrawal

    History of substance abuse

    ...and 3 more risk factors

  • Suicidal thoughts or behavior

    Severe depression

  • Driving impairment

    Taking with alcohol or drugs

  • Drug interactions

    Current liver problems

    ...and 1 more risk factors

See more detailed risks and warnings
  • Withdrawal symptoms

    Taking Librium (chlordiazepoxide) for more than 2 weeks

  • Drowsiness and sleepiness

    Drinking alcohol or taking narcotics

See more detailed risks and warnings