Compare Xanax vs. Vistaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Xanax
(alprazolam)

Vistaril
(hydroxyzine pamoate)

Helps you relax. Xanax (Alprazolam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and longer-term for panic attacks. More likely to cause withdrawal symptoms compared to similar drugs.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.35Xanax
Reviews for Xanax
74%
of people (All ages) say Xanax is worth it
55%
say it works well
13%
say it's a big hassle
1287 reviews
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it

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Have you used Vistaril (hydroxyzine pamoate)?
Worth itNot sureNot worth it
Side effects
XanaxVistaril
  • Drowsiness 34%
  • Fatigue and Tiredness 6%
  • Impaired Coordination 23%
  • Irritability 3%
  • Memory Impairment 11%
  • Increased Appetite 10%
More Xanax side effects »

We haven’t found good data for Vistaril side effects.

FDA side effect reports for Vistaril »
How it works
XanaxVistaril
Xanax (Alprazolam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Coming soon.
Type of medication
XanaxVistaril
Prescription only
Available as
XanaxVistaril
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid
Used for
XanaxVistaril
  • Anxiety Pruritus Sedation Adjunct
Risk factors for serious side effects
XanaxVistaril
  • History of drug abuse
  • Taking with alcohol or drugs
  • Taking more than 4 mg/day or longer than 12 weeks
  • Stopping Xanax (Alprazolam) suddenly
  • Severely depressed
Detailed Xanax (alprazolam) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    XanaxVistaril
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    No alcohol related info.
    Kidneys and liver
    XanaxVistaril
    • Processed by the liver, so might not be the best choice if you have liver problems.
    No kidneys and liver related info.
    Sleep
    XanaxVistaril
    • Can cause temporary dizziness and drowsiness.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    No sleep related info.
    Upsides and benefits
    XanaxVistaril
    • Effective at relieving short-term anxiety.
    • Effective longer-term for panic attacks.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    Coming soon
    Downsides and risks
    XanaxVistaril
    • Processed by the liver, so might not be the best choice if you have liver problems.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
    Coming soon
    Tips from our pharmacists for people taking the medication
    XanaxVistaril
    • Good for short-term relief of anxiety symptoms.
    • Starts working in 45 minutes when swallowed.
    • Can cause temporary dizziness and drowsiness.
    • Addictive. Long-term use can cause dependence or abuse.
    • Not safe to use with alcohol.
    Coming soon
    Learn more
    More about XanaxSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Xanax (alprazolam)?
    Worth itNot sureNot worth it
    More about VistarilSide effectsReviews & ratingsFDA package insert
    Have you used Vistaril (hydroxyzine pamoate)?
    Worth itNot sureNot worth it