Compare Xarelto vs. Heparin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Xarelto
(rivaroxaban)

heparin

Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.82Xarelto
Reviews for Xarelto
45%
of people (All ages) say Xarelto is worth it
45%
say it works well
9%
say it's a big hassle
Have you used Xarelto (rivaroxaban)?
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Have you used Heparin?
Worth itNot sureNot worth it
Side effects
XareltoHeparin
  • Bleeding in the stomach & intestines 2%
  • Major bleeding needing transfusion 4%
  • Clinically relevant but not major bleeding 9%
  • Complaints of bleeding 28%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Back pain 3%
  • Pain in the arms or legs 2%
  • Itching 2%
  • Wound drainage 3%
More Xarelto side effects »

We haven’t found good data for Heparin side effects.

FDA side effect reports for Heparin »
How it works
XareltoHeparin
Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.Heparin is an anticoagulant that binds with proteins and platelets to stop blood clots from being made and traveling to the brain, heart, and lungs.
Type of medication
XareltoHeparin
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
XareltoHeparin
  • Pill
  • Injection
Used for
XareltoHeparin
Risk factors for serious side effects
XareltoHeparin
  • Stopping Xarelto (rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
Detailed Xarelto (rivaroxaban) risks & warnings »
  • History of bleeding problems
  • Severe high blood pressure
  • Older age
  • Heparin-induced thrombocytopenia
Detailed Heparin risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
XareltoHeparin
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
No interactions related info.
Food
XareltoHeparin
  • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
No food related info.
Kidneys and liver
XareltoHeparin
  • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
No kidneys and liver related info.
Upsides and benefits
XareltoHeparin
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
  • Safe to use in pregnancy and if you're breast feeding.
  • There are other medications that can help stop unexpected bleeding while taking Heparin.
  • Available as a generic medication.
  • Usually used in the hospital, but can be given at home too.
Downsides and risks
XareltoHeparin
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
  • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
  • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
Tips from our pharmacists for people taking the medication
XareltoHeparin
  • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
  • If you completely forget to take a dose, call your doctor right away.
  • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
  • Make sure to change where you inject Heparin every time.
  • Don't take aspirin or other anti-inflammatory medications without talking to your doctor first.
  • You will have to do regular blood draws or labs to make sure that Heparin is working for you.
Learn more
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it
More about HeparinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Heparin?
Worth itNot sureNot worth it